GSDME

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSDME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GSDME (Gasdermin E/DFNA5) encodes a pore-forming protein executing pyroptosis, implicated in neuronal death in AD, PD, ALS, and stroke.

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graph TD
    GSDME["<b>GSDME</b>"]
    Cancer{"Cancer"}
    GSDME -->|"activates"| Cancer
    Ms{"Ms"}
    GSDME -->|"activates"| Ms
    Tumor{"Tumor"}
    GSDME -->|"activates"| Tumor
    GSDME -->|"inhibits"| Cancer
    Als{"Als"}
    GSDME -->|"activates"| Als
    GSDME -->|"therapeutic target"| Ms
    Atherosclerosis{"Atherosclerosis"}
    GSDME -->|"activates"| Atherosclerosis
    Cardiovascular{"Cardiovascular"}
    GSDME -->|"regulates"| Cardiovascular
    GSDME -->|"regulates"| Atherosclerosis
    Leukemia{"Leukemia"}
    GSDME -->|"activates"| Leukemia
    Carcinoma{"Carcinoma"}
    GSDME -->|"inhibits"| Carcinoma
    ALS{"ALS"}
    GSDME -->|"degrades"| ALS
    CALR["CALR"]
    CALR -->|"activates"| GSDME
    NLRP3["NLRP3"]
    NLRP3 -->|"expressed in"| GSDME
    NLRP3 -->|"regulates"| GSDME
    GENES["GENES"]
    GENES -->|"activates"| GSDME
    CD8["CD8"]
    CD8 -->|"activates"| GSDME
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"activates"| GSDME
    PYROPTOSIS -->|"inhibits"| GSDME
    PJA1["PJA1"]
    PJA1 -->|"inhibits"| GSDME
    PHAGOCYTOSIS["PHAGOCYTOSIS"]
    PHAGOCYTOSIS -->|"activates"| GSDME
    STAT3["STAT3"]
    STAT3 -->|"activates"| GSDME
    AND["AND"]
    AND -->|"activates"| GSDME
    CANCER["CANCER"]
    CANCER -->|"activates"| GSDME
    style GSDME fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0