gene

PLPPR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLPPR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PLPPR1: Lipid phosphate phosphatase regulating LPA and S1P signaling in neuronal development and neurodegeneration

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🧬 Gene Info

Gene Symbol	PLPPR1
Full Name	Phospholipid Phosphatase-Related Protein 1
Chromosome	9p13.3
Protein Type	Phosphatase
Function	is a member of the lipid phosphate phosphatase (LPP) family within the broader family of phosphatidic acid phosphatases (PAPs).
Amino Acids	50 aa
UniProt ID	[Q9Y329](https://www.uniprot.org/uniprot/Q9Y329)
Ensembl ID	ENSG00000143125
GeneCards	PLPPR1
Human Protein Atlas	PLPPR1
LPA regulation	Dephosphorylates LPA to monoacylglycerol (MAG), terminating LPA signaling
S1P regulation	Modulates S1P levels, affecting cell survival and migration
Spatial signaling	Shapes lipid gradients important for cell-cell communication
Associated Diseases	Parkinson's disease, Alzheimer's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PLPPR1 Gene

gene · 1594 words

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Pathway Diagram

graph TD
    PLPPR1["PLPPR1"]
    neurodegeneration["neurodegeneration"]
    PLPPR1 -->|"implicated_in"| neurodegeneration
    style PLPPR1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PLPPR1 in their description or question text

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