Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PPID: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PPID encodes peptidylprolyl isomerase D (cyclophilin D), a mitochondrial cyclophilin that regulates the mitochondrial permeability transition pore (mPTP). Critical for mitochondrial function and cell death pathways in Alzheimer's and Parkinson's disease.
| Gene Symbol | PPID |
| Full Name | Peptidylprolyl Isomerase D (Cyclophilin D) |
| Aliases | cyclophilin D |
| Chromosome | 4q31.3 |
| Protein Type | Channel |
| Function | is a nuclear-encoded mitochondrial cyclophilin protein that plays a critical role in regulating the mitochondrial permeability transition pore (mPTP). |
| Primary Expression | all major neuronal populations in the cerebral cortex, hippocampus, basal ganglia, cerebellum, and brainstem [9] |
| Molecular Weight | ~41 kDa |
| Amino Acids | 323 aa |
| UniProt ID | Q8WWC6 |
| NCBI Gene ID | 54840 |
| Ensembl ID | ENSG00000117595 |
| GeneCards | PPID |
| Human Protein Atlas | PPID |
| Protein Class | Immunophilin, Mitochondrial cyclophilin |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["PPID"]
N1["Mitochondrial Dysfunction"]
N0 -->|"associated with"| N1
N2["neurodegeneration"]
N0 -->|"implicated in"| N2
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 mechanism| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||