gene

PPID

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPID: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

1Analyses

1Outgoing

2Incoming

0Experiments

1Debates

Summary

PPID encodes peptidylprolyl isomerase D (cyclophilin D), a mitochondrial cyclophilin that regulates the mitochondrial permeability transition pore (mPTP). Critical for mitochondrial function and cell death pathways in Alzheimer's and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	PPID
Full Name	Peptidylprolyl Isomerase D
Aliases	cyclophilin D
Chromosome	4q31.3
Protein Type	Channel
Function	is a nuclear-encoded mitochondrial cyclophilin protein that plays a critical role in regulating the mitochondrial permeability transition pore (mPTP).
Primary Expression	all major neuronal populations in the cerebral cortex, hippocampus, basal ganglia, cerebellum, and brainstem [9]
Molecular Weight	41 kDa
Amino Acids	323 aa
UniProt ID	Q8WWC6
NCBI Gene ID	54840
Ensembl ID	ENSG00000117595
GeneCards	PPID
Human Protein Atlas	PPID
PPIase domain	Catalyzes cis-trans isomerization of peptidyl-prolyl bonds
Associated Diseases	Alzheimer's disease, Parkinson's disease
KG Connections	3 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PPID — AlphaFold Q8WWC6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPID — Peptidylprolyl Isomerase D

gene · 1871 words

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Pathway Diagram

flowchart TD
    N0["PPID"]
    N1["Mitochondrial Dysfunction"]
    N0 -->|"associated with"| N1
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 mechanism

Outgoing (1)

Target	Relation	Type	Str
mPTP opening	regulates	mechanism	0.90

Incoming (2)

Source	Relation	Type	Str
genes-ppid	linked_to	wiki	1.00
HSP90	regulates	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.693

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While the study demonstrates TDP-43 triggers mPTP-mediated mtDNA release, the mo

closed · Rounds: 4 · Score: 0.77 · 2026-04-21

Related Research

Hypotheses and analyses mentioning PPID in their description or question text

No additional research found