gene

PPP1CC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP1CC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

1Outgoing

3Incoming

0Experiments

0Debates

Summary

PPP1CC encodes the gamma isoform of protein phosphatase 1 catalytic subunit, a key serine/threonine phosphatase regulating metabolism, synaptic plasticity, and tau phosphorylation.

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🧬 Gene Info

Gene Symbol	PPP1CC
Full Name	Protein Phosphatase 1 Catalytic Subunit Gamma
Chromosome	12p13.21
Protein Type	Enzyme
Function	is a 323 amino acid enzyme with
Primary Expression	Ubiquitous; highest in brain, testis, kidney
Amino Acids	323 aa
UniProt ID	P36818
NCBI Gene ID	5501
Ensembl ID	ENSG00000185641
OMIM	176001
GeneCards	PPP1CC
Human Protein Atlas	PPP1CC
Associated Diseases	Als
KG Connections	4 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PPP1CC — AlphaFold P36818 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPP1CC Gene - Protein Phosphatase 1 Catalytic Subunit Gamma

gene · 1201 words

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Pathway Diagram

graph TD
    PPP1CC["PPP1CC"]
    Als{"Als"}
    PPP1CC -->|"associated with"| Als
    neurodegeneration["neurodegeneration"]
    PPP1CC -->|"implicated in"| neurodegeneration
    LMNA["LMNA"]
    LMNA -->|"associated with"| PPP1CC
    RIPK3["RIPK3"]
    RIPK3 -->|"associated with"| PPP1CC
    JAK2["JAK2"]
    JAK2 -->|"associated with"| PPP1CC
    style PPP1CC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
Als	associated_with	disease	0.65

Incoming (3)

Source	Relation	Type	Str
LMNA	associated_with	gene	0.60
RIPK3	associated_with	gene	0.60
JAK2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP1CC in their description or question text

No additional research found