JAK2

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

JAK2 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with ALS, Aging, Als. Connected to 467 entities in the SciDEX knowledge graph.

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graph TD
    JAK2["JAK2<br/>Janus Kinase 2"] -->|"activates"| STAT["STAT Signaling"]
    JAK2 -->|"activates"| Inflammation["Inflammation"]
    JAK2 -->|"activates"| Immune["Immune Response"]
    JAK2 -->|"activates"| CSF1R["CSF1R"]
    JAK2 -->|"regulates"| GFAP["GFAP"]
    JAK2 -->|"regulates"| GPX4["GPX4"]

    JAK2 -->|"inhibits"| AKT["AKT Pathway"]
    JAK2 -->|"inhibits"| Apoptosis["Apoptosis"]
    JAK2 -->|"inhibits"| Endocytosis["Endocytosis"]

    ABL1["ABL1"] -->|"activates"| JAK2
    ABL2["ABL2"] -->|"activates"| JAK2
    IL7R["IL7R"] -->|"contributes to"| JAK2
    EPOR["EPOR"] -.->|"contributes to"| JAK2

    JAK2 -->|"inhibits"| Alzheimer["Alzheimer's Disease"]
    JAK2 -->|"therapeutic target"| Cancer["Cancer"]
    JAK2 -->|"activates"| Fibrosis["Fibrosis"]
    JAK2 -->|"activates"| ALS["ALS"]

    style JAK2 fill:#e74c3c,stroke:#c0392b,color:#e0e0e0
    style STAT fill:#3498db,stroke:#2980b9,color:#e0e0e0
    style Inflammation fill:#f39c12,stroke:#e67e22,color:#e0e0e0
    style Alzheimer fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0
    style Cancer fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0