gene

RIPK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RIPK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1470Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

RIPK3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 632 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RIPK3
Full Name	Receptor-Interacting Serine/Threonine-Protein Kinase 3
Chromosome	14q11.2
Function	Necrosome formation: RHIM-RHIM interactions recruit RIPK3 to activated RIPK1; RIPK1 undergoes conformational change exposing its RHIM
Primary Expression	Restrictive — immune cells, neurons, some epithelial cells
Molecular Weight	~57 kDa
Amino Acids	527 aa
Pathways	Apoptosis, Autophagy, Dna Methylation, Ferroptosis, Immune Response
UniProt ID	Q9Y2K6
NCBI Gene ID	8767
Ensembl ID	ENSG00000129465
OMIM	604466
GeneCards	RIPK3
Human Protein Atlas	RIPK3
Protein Size	518 amino acids
Associated Diseases	AD, ALI, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS
Known Drugs/Compounds	RAPAMYCIN, Adeno-Associated Virus, THSG, Mitochondrial ROS, Ponicidin, HSYA
Interactions	DRP1, CHOP, BECN1, PTEN, DDIT3, NBR1
KG Connections	1470 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    RIPK3(["RIPK3"])
    Necroptosis["Necroptosis"]
    Inflammation["Inflammation"]
    Cell_Death("Cell Death")
    MLKL(["MLKL"])
    INFLAMMATION(["INFLAMMATION"])
    Cancer["Cancer"]
    RIPK1(["RIPK1"])
    Apoptosis["Apoptosis"]
    Pyroptosis["Pyroptosis"]
    Inflammasome["Inflammasome"]
    TNF(["TNF"])

    RIPK3 -->|"regulates"| Necroptosis
    RIPK3 -->|"activates"| Inflammation
    RIPK3 -->|"regulates"| Cell_Death
    RIPK3 -->|"activates"| Necroptosis
    RIPK3 -->|"regulates"| MLKL
    INFLAMMATION -->|"activates"| RIPK3
    RIPK3 -->|"therapeutic target"| Cancer
    RIPK3 -->|"regulates"| RIPK1
    RIPK3 -->|"activates"| Apoptosis
    RIPK3 -->|"therapeutic target"| Pyroptosis
    RIPK3 -->|"therapeutic target"| Apoptosis
    RIPK3 -->|"regulates"| Apoptosis
    RIPK3 -->|"activates"| Inflammasome
    RIPK3 -->|"therapeutic target"| Necroptosis
    TNF -->|"activates"| RIPK3

    style RIPK3 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (764)

Target	Relation	Type	Str
Necroptosis	regulates	pathway	1.00
PANoptosis	component_of	process	0.95
Antiviral gene transcription	activates	process	0.95
Inflammation	activates	disease	0.95
Necroptosis	component_of	pathway	0.95
Necroptosis	mediates	process	0.95
Cell Death	regulates	process	0.90
Axonal Degeneration	mediates	process	0.90
PANoptosis	regulates	process	0.90
Panoptosis	activates	process	0.90
TRIF	interacts_with	protein	0.90
tumor cell death	associated_with	phenotype	0.90
MLKL	phosphorylates	protein	0.90
Necroinflammation	involved_in	process	0.90
NF-κB	activates	protein	0.90
Necroptosis	involved_in	process	0.90
necroptosis	participates_in	pathway	0.90
Neuron	expressed_in	entity	0.90
MLKL	regulates	gene	0.90
Necroptosis	activates	pathway	0.90
myocardial inflammation	promotes	process	0.88
Lytic Cell Death	mediates	process	0.88
Proinflammatory Mediators	upregulates	process	0.88
NFKB	activates	protein	0.87
Antitumor Immunity	contributes_to	process	0.85
DAMPs	associated_with	compound	0.85
Lytic Cell Death	associated_with	process	0.85
PANoptosis	mediates	process	0.85
Cytokines	regulates	protein	0.85
Cancer	therapeutic_target	disease	0.85
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.85
IL-6	upstream_of	protein	0.85
antitumor immunity	potentiates	process	0.80
neuroinflammation	activates	disease	0.80
oxidative stress response	participates_in	pathway	0.80
RIPK1	regulates	gene	0.80
Apoptosis	activates	pathway	0.80
Pyroptosis	therapeutic_target	pathway	0.80
Apoptosis	therapeutic_target	pathway	0.80
Apoptosis	regulates	pathway	0.80
Inflammasome	activates	pathway	0.80
Necroptosis	therapeutic_target	pathway	0.80
Stevens-Johnson Syndrome	biomarker_for	disease	0.75
Cancer	activates	disease	0.75
Tumor	activates	disease	0.75
Als	regulates	disease	0.75
Amyotrophic Lateral Sclerosis	regulates	disease	0.75
Als	activates	disease	0.75
Als	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75

Incoming (706)

Source	Relation	Type	Str
PARP12	mono-ADP-ribosylates	gene	0.90
INFLAMMATION	activates	gene	0.90
adeno-associated viruses	associated_with	drug	0.85
Mitochondrial ROS	activates	compound	0.85
HSYA	binds	compound	0.85
Adeno-Associated Virus	targets	drug	0.80
THSG	inhibits	compound	0.80
Ponicidin	inhibits	compound	0.80
TNF	activates	gene	0.80
APOPTOSIS	activates	gene	0.80
APOPTOSIS	therapeutic_target	gene	0.80
RIPK1	regulates	gene	0.70
BAX	activates	gene	0.70
NLRP3	regulates	gene	0.70
BECN1	regulates	gene	0.70
LC3	regulates	gene	0.70
RIPK1	implicated_in	gene	0.70
ERN1	regulates	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.70
APOPTOSIS	regulates	gene	0.70
INFLAMMATION	regulates	gene	0.70
PYROPTOSIS	activates	gene	0.70
PYROPTOSIS	regulates	gene	0.70
PYROPTOSIS	therapeutic_target	gene	0.70
ATG	activates	gene	0.70
ATG	regulates	gene	0.70
NLR	activates	gene	0.70
NLR	regulates	gene	0.70
MLKL	mediates	gene	0.65
RIPK1	causes	gene	0.65
MTOR	activates	gene	0.65
PI3K	activates	gene	0.65
PYCARD	activates	gene	0.65
DENDRITIC CELL	activates	cell_type	0.65
ATP	activates	gene	0.65
NEURONS	causes	cell_type	0.65
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RIPK3

Understanding Entity Pages

Summary

Wiki Pages (21)

RIPK3 Gene

cbs-psp-daily-action-plan

Necroptotic Neurons

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

Necroptosis Pathway in Neurodegeneration

Mechanisms Dashboard

Apoptosis in Neurodegeneration

Regulated Necrosis Hypothesis in Parkinson's Disease

Cell Death Pathways in 4R-Tauopathies

ZBP1 (Z-DNA Binding Protein 1)

Ferroptosis

Caspase-3 Protein

CFLAR

MAP3K4 — Mitogen-Activated Protein Kinase Kinase Kinase 4

Pyroptosis

Necroptosis in Alzheimer's Disease

casp8