gene

PPP1R15B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP1R15B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

6Outgoing

2Incoming

0Experiments

0Debates

Summary

Protein Phosphatase 1 Regulatory Subunit 15B (CReP) - key regulator of integrated stress response, implicated in Alzheimer's and Parkinson's disease

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🧬 Gene Info

Gene Symbol	PPP1R15B
Full Name	Protein Phosphatase 1 Regulatory Subunit 15B
Aliases	Protein Phosphatase 1 Regulatory Subunit 15B (CReP)
Chromosome	1q21.3
Protein Type	Phosphatase
Function	This complex specifically targets the alpha subunit of eukaryotic initiation factor 2 (eIF2α)
Amino Acids	684 aa
UniProt ID	Q9H0X4
NCBI Gene ID	84919
Ensembl ID	ENSG00000167524
GeneCards	PPP1R15B
Human Protein Atlas	PPP1R15B
CReP protein	684 amino acids, contains PP1-binding motif
PP1 catalytic subunit	Provides the phosphatase activity
Substrate specificity	The CReP regulatory subunit directs PP1 to dephosphorylate specifically eIF2α
Associated Diseases	neurodegeneration
Interactions	MUL1, UBIQUITIN
KG Connections	8 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PPP1R15B — AlphaFold Q9H0X4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPP1R15B

gene · 2982 words

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Pathway Diagram

graph TD
    PPP1R15B["PPP1R15B"]
    Als{"Als"}
    PPP1R15B -->|"contributes to"| Als
    MUL1["MUL1"]
    PPP1R15B -->|"interacts with"| MUL1
    VCP["VCP"]
    PPP1R15B -->|"contributes to"| VCP
    UBIQUITIN["UBIQUITIN"]
    PPP1R15B -->|"interacts with"| UBIQUITIN
    neurodegeneration["neurodegeneration"]
    PPP1R15B -->|"implicated in"| neurodegeneration
    style PPP1R15B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PPP1R15B	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Als	contributes_to	disease	0.65
MUL1	interacts_with	gene	0.60
VCP	contributes_to	gene	0.60
UBIQUITIN	interacts_with	gene	0.60

Incoming (2)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PPP1R15B	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP1R15B in their description or question text

No additional research found