MUL1

Understanding Entity Pages

This page aggregates everything SciDEX knows about MUL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

MUL1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 306 entities in the SciDEX knowledge graph.

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flowchart TD
    MUL1["MUL1<br/>E3 Ubiquitin Ligase"]
    
    DRP1["DRP1<br/>Mitochondrial Fission"]
    BNIP3["BNIP3<br/>Mitophagy Receptor"]
    BECN1["BECN1<br/>Autophagy Initiation"]
    NBR1["NBR1<br/>Autophagy Adapter"]
    
    CHOP["CHOP/DDIT3<br/>ER Stress Response"]
    EIF2S1["EIF2S1<br/>Translation Control"]
    RIPK3["RIPK3<br/>Necroptosis"]
    MAPK8["MAPK8/JNK<br/>Stress Signaling"]
    
    PTEN["PTEN<br/>PI3K/AKT Inhibitor"]
    DISC1["DISC1<br/>Neurodevelopment"]
    
    Mitophagy["Mitochondrial<br/>Quality Control"]
    ER_Stress["ER Stress<br/>Response"]
    Cell_Death["Neuronal<br/>Cell Death"]
    
    Alzheimer["Alzheimer's<br/>Disease"]
    Parkinson["Parkinson's<br/>Disease"]
    ALS["Amyotrophic<br/>Lateral Sclerosis"]
    FTD["Frontotemporal<br/>Dementia"]
    
    MUL1 --|"regulates"|--> DRP1
    MUL1 --|"activates"|--> BNIP3
    MUL1 --|"promotes"|--> BECN1
    MUL1 --|"interacts"|--> NBR1
    
    DRP1 --|"promotes"|--> Mitophagy
    BNIP3 --|"promotes"|--> Mitophagy
    BECN1 --|"promotes"|--> Mitophagy
    NBR1 --|"promotes"|--> Mitophagy
    
    MUL1 --|"interacts"|--> CHOP
    MUL1 --|"regulates"|--> EIF2S1
    CHOP --|"promotes"|--> ER_Stress
    EIF2S1 --|"regulates"|--> ER_Stress
    
    MUL1 --|"inhibits"|--> RIPK3
    MUL1 --|"modulates"|--> MAPK8
    RIPK3 --|"promotes"|--> Cell_Death
    MAPK8 --|"promotes"|--> Cell_Death
    
    MUL1 --|"interacts"|--> PTEN
    MUL1 --|"interacts"|--> DISC1
    
    ER_Stress --|"contributes"|--> Cell_Death
    Cell_Death --|"leads_to"|--> Alzheimer
    Cell_Death --|"leads_to"|--> Parkinson
    Cell_Death --|"leads_to"|--> ALS
    Cell_Death --|"leads_to"|--> FTD
    
    style MUL1 fill:#006494
    style Mitophagy fill:#1b5e20
    style BECN1 fill:#1b5e20
    style BNIP3 fill:#1b5e20
    style NBR1 fill:#1b5e20
    style PTEN fill:#4a1a6b
    style DISC1 fill:#4a1a6b
    style CHOP fill:#ef5350
    style RIPK3 fill:#ef5350
    style ER_Stress fill:#ef5350
    style Cell_Death fill:#ef5350
    style Alzheimer fill:#5d4400
    style Parkinson fill:#5d4400
    style ALS fill:#5d4400
    style FTD fill:#5d4400