Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PANCREATIC DUCTAL ADENOCARCINOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PANCREATIC DUCTAL ADENOCARCINOMA |
Knowledge base pages for this entity
graph TD
PANCREATIC_DUCTAL_ADENOCARCINO["PANCREATIC DUCTAL ADENOCARCINOMA"]
Cancer_Associated_Fibroblast_A["Cancer-Associated Fibroblast Autophagy"] -->|"involved_in"| PANCREATIC_DUCTAL_ADENOCARCINO
KRAS["KRAS"] -->|"risk_factor_for"| PANCREATIC_DUCTAL_ADENOCARCINO
STAT3["STAT3"] -->|"target for"| PANCREATIC_DUCTAL_ADENOCARCINO
UFMylation["UFMylation"] -->|"promotes"| PANCREATIC_DUCTAL_ADENOCARCINO
RAS["RAS"] -->|"risk_factor_for"| PANCREATIC_DUCTAL_ADENOCARCINO
Epigenetic_Regulation["Epigenetic Regulation"] -->|"involved_in"| PANCREATIC_DUCTAL_ADENOCARCINO
SIK1["SIK1"] -.biomarker for.-> PANCREATIC_DUCTAL_ADENOCARCINO| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| PRMT1 | associated_with | gene | 0.95 |
| Cancer-Associated Fibroblast Autophagy | involved_in | process | 0.95 |
| KRAS | risk_factor_for | gene | 0.95 |
| STAT3 | therapeutic_target | gene | 0.92 |
| UFMylation | promotes | process | 0.92 |
| Cancer-Associated Fibroblast Autophagy Inhibition | treats | mechanism | 0.90 |
| PI3K/AKT/mTOR Pathway | involved_in | pathway | 0.90 |
| RAS | risk_factor_for | gene | 0.90 |
| Epigenetic Regulation | involved_in | process | 0.85 |
| Mitochondrial Fission | associated_with | process | 0.85 |
| PRMT1 | promotes | protein | 0.85 |
| PRMT1 | therapeutic_target | protein | 0.85 |
| SIK1 | biomarker_for | gene | 0.85 |
| immunostimulatory repeat expression | upstream_of | process | 0.80 |
| gemcitabine | treats | drug | 0.80 |
| FGF21 | protects_against | protein | 0.70 |
| oxaliplatin | treats | drug | 0.70 |
| M2-TAM polarization reversal | protects_against | process | 0.70 |
| PI3K/AKT/mTOR Pathway Inhibitors | treats | drug | 0.70 |
| PRMT1 | implicated_in | gene | 0.50 |
| KRAS | implicated_in | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||