Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about OXALIPLATIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | OXALIPLATIN |
| Key Genes/Proteins | IL18, NLRP3, TLR4, JNK |
| Related Diseases | NEUROPATHY, CANCER |
| Related Pathways | NLRP3 INFLAMMASOME |
Knowledge base pages for this entity
graph TD
OXALIPLATIN["OXALIPLATIN"]
OXALIPLATIN -->|"causes"| Chemotherapy_Induced_Periphera["Chemotherapy-Induced Peripheral Neuropathy"]
OXALIPLATIN -->|"treats"| pancreatic_ductal_adenocarcino["pancreatic ductal adenocarcinoma"]
OXALIPLATIN -->|"activates"| NEUROPATHY["NEUROPATHY"]
CANCER["CANCER"] -->|"treats"| OXALIPLATIN
NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -.protects against.-> OXALIPLATIN
n_17_DMAG["17-DMAG"] -->|"activates"| OXALIPLATIN| Target | Relation | Type | Str |
|---|---|---|---|
| NEUROPATHY | activates | disease | 0.65 |
| VINCRISTINE | associated_with | drug | 0.45 |
| PACLITAXEL | associated_with | drug | 0.45 |
| BORTEZOMIB | associated_with | drug | 0.45 |
| NEUROPATHY | associated_with | disease | 0.45 |
| CISPLATIN | associated_with | drug | 0.45 |
| NLRP3 | associated_with | gene | 0.45 |
| CANCER | associated_with | disease | 0.45 |
| TLR4 | associated_with | gene | 0.45 |
| JNK | associated_with | gene | 0.45 |
| IL18 | associated_with | gene | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CANCER | treats | disease | 0.65 |
| NLRP3 INFLAMMASOME | protects_against | pathway | 0.65 |
| IL18 | protects_against | gene | 0.65 |
| NLRP3 INFLAMMASOME | associated_with | pathway | 0.45 |
| BORTEZOMIB | associated_with | drug | 0.45 |
| CISPLATIN | associated_with | drug | 0.45 |
| NEUROPATHY | associated_with | disease | 0.45 |
| 5-FLUOROURACIL | associated_with | drug | 0.45 |
| NLRP3 | associated_with | gene | 0.45 |
| CANCER | associated_with | disease | 0.45 |
| JNK | associated_with | gene | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||