gene

RAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3650Connections
14Hypotheses
2Analyses
50Outgoing
50Incoming

Summary

RAS is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with AD, ADH, ALS. Connected to 1154 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRAS
Full NameRussian Academy of Sciences
Protein TypeNational Academy of Sciences
PathwaysAPOPTOSIS
GeneCardsRAS
Human Protein AtlasRAS
LocationMoscow, Russia
Founded1724
Websitehttps://www.ras.ru
Associated DiseasesAD, ADH, ALS, AMI, Aging
Known Drugs/CompoundsKRAS inhibitors, SEMAGLUTIDE, RAPAMYCIN, Lonafarnib, MNNG, angiotensin receptor blockers
InteractionsROS, UBIQUITIN, DNM1L, CTSD, ATG, HIF1A
KG Connections2322 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Russian Academy of Sciences

institution · 844 words

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

Novel Therapy Index

idea · 10647 words

CBS/PSP Supplements Guide

therapeutic · 6929 words

Device Therapies Comparison for CBS/PSP

therapeutic · 6867 words

Pathway Diagram

graph TD
    RAS["RAS"] -->|"regulates"| Ischemia["Ischemia"]
    RAS["RAS"] -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    RAS["RAS"] -->|"interacts"| Alzheimer["Alzheimer"]
    RAS["RAS"] -->|"interacts"| ALS["ALS"]
    RAS["RAS"] -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    RAS["RAS"] -->|"interacts"| Dementia["Dementia"]
    NF1["NF1"] -->|"regulates"| RAS["RAS"]
    CAMP["CAMP"] -->|"activates"| RAS["RAS"]
    MTOR["MTOR"] -->|"regulates"| RAS["RAS"]
    MYC["MYC"] -->|"regulates"| RAS["RAS"]
    style RAS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1493)

TargetRelationTypeStr
Tumoractivatesdisease1.00
Cancerassociated_withdisease1.00
Canceractivatesdisease1.00
Apoptosisactivatespathway1.00
Autophagyactivatespathway1.00

Incoming (2157)

SourceRelationTypeStr
APOPTOSISactivatesgene1.00
PI3Kactivatesgene1.00
ERKactivatesgene1.00
KRASactivatesgene1.00
RAPAMYCINactivatesdrug0.95

Targeting Hypotheses (14)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Closed-loop transcranial focused ultrasound to restore hippo 0.709 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur 0.697 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with 40Hz gamma 0.689 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo 0.633 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II 0.633 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting CA1 PV interneurons 0.614 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo 0.614 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II 0.612 Alzheimer's disease Circuit-level neural dynamics in neurode
Selective APOE4 Degradation via Proteolysis Targeting Chimer 0.595 neurodegeneration APOE4 structural biology and therapeutic
Closed-loop focused ultrasound targeting EC-II PV interneuro 0.568 Alzheimer's disease Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe 0.538 Alzheimer's disease Circuit-level neural dynamics in neurode
Epigenetic Memory Erasure via TET2 Activation 0.515 neurodegeneration Astrocyte reactivity subtypes in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV 0.508 Alzheimer's disease Circuit-level neural dynamics in neurode
Astrocyte-Mediated Microglial Memory Erasure 0.462 - Neuroinflammation and microglial priming

Mentioning Analyses (2)

Scientific analyses that reference this entity

What is the optimal BBB opening duration and spatial precision to maximize thera

neuropharmacology | 2026-04-11 | 0 hypotheses

What specific astrocyte-derived factors can 'erase' pathological microglial memo

neuroinflammation | 2026-04-08 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegenerat [PMID:37995685] Litvinchuk A, Suh JH, Guo JL, Lin K, Dav Neuron 2024 1
The cell biology of APOE in the brain. [PMID:37805344] Windham IA, Cohen S Trends Cell Biol 2024 1
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317] Maxine R Nelson, Peng Liu, Ayushi Agrawa Nature neuroscience 2023 1
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485] Serrano-Pozo A, Das S, Hyman BT Lancet Neurol 2021 1
Lysosome-targeting chimaeras for degradation of extracellular proteins. [PMID:32728216] Banik SM, Pedram K, Wisnovsky S, Ahn G, Nature 2020 1
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456] Long JM, Holtzman DM Cell 2019 1
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008] Yamazaki Y, Zhao N, Caulfield TR, Liu CC Nat Rev Neurol 2019 1
Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associate [PMID:41905188] Cetindag AC, Schipke CG, Esselmann H, Kr The journal of prevention of A 2026 0
Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635] Thedim M, Hu J, Maher M, Wiener-Kronish Br J Anaesth 2026 0
Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639] Bae H, Song Z, Ali A, Sasaki T, Tesi N e Geroscience 2026 0
Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401] Stern A, Linial M Geroscience 2026 0
Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasi [PMID:40886963] Zhu L, Du L, Wu J, Ding D, Wang J et al. J Invest Dermatol 2026 0
Restoration of p53 mRNA combined with BRD4 silencing by brain targeted nanocapsu [PMID:41101204] Sang Y, Cao Y, Li S, Quan Y, Wang S et a Biomaterials 2026 0
Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β path [PMID:41445196] Lin Z, Xiong J, Zhang F, Zhang H, Zhu M Mol Ther 2026 0
Menopause, cognition, and Alzheimer's disease risk. [PMID:41531227] Samudra N, Vemuri M, Weitlauf J Curr Opin Obstet Gynecol 2026 0
ApoE-directed CpG nano-immunoadjuvant ameliorates Alzheimer's-like pathology in [PMID:41651379] Huang X, Sun YY, Qin YR, Chen H, Pan TT J Control Release 2026 0
Albofungin vesicle nanobombs trigger lysosomal disruption for self-enhanced pyro [PMID:41679437] Chen C, Tan S, Zhu X, Song Z, Xing Y et J Control Release 2026 0
Covalent Bond Locking in Semiconducting Oligomers Boosts Ultrabright NIR-II Lumi [PMID:41757652] Li X, Gan H, Zhang C, Gao Y, Zhang J et Angew Chem Int Ed Engl 2026 0
Inflammation-related miR-155-5p as an APOE ε4-modulated biomarker for amyloid pa [PMID:41930593] Yoshida K, Saito N, Takahashi R, Ando S, J Alzheimers Dis 2026 0
UBE2I Alleviates Pyroptosis in Coronary Heart Disease by Promoting the SUMOylati [PMID:41930933] Ding SK Immunol Invest 2026 0