Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Pathology: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Amyotrophic Lateral Sclerosis | associated_with | disease | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbate | 0.610 | - | Do β-amyloid plaques and neurofibrillary |
| Vascular mural cell degeneration precedes and exacerbates pa | 0.520 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 0 hypotheses
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.567
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.552
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.596
neurodegeneration | 2026-04-13 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990] | Keller A | Annual review of physiology | 2026 | 0 |
| Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in h [PMID:40902811] | Wang Y, Zhang Z, Cao L, Huang S, Huang X | J Ethnopharmacol | 2026 | 0 |
| Based on network pharmacology and experiments to investigate the inhibitory effe [PMID:41308710] | Yang X, Xiao JH, Li X, Liu RM, Yuan Q | J Ethnopharmacol | 2026 | 0 |
| Novel insights into meningioma brain invasion with spatial transcriptomic profil [PMID:41486296] | Maier AD, Laurentiussen CO, Michaelsen S | Acta Neuropathol Commun | 2026 | 0 |
| Brain vascular stability relies on PAK2-cilia-PDGF-BB-HSPGs on basolateral side [PMID:41490797] | Prabhudesai S, Thirugnanam K, Song X, Ya | Life Sci Alliance | 2026 | 0 |
| Plasma platelet-derived growth factor receptor-β decrease correlates with blood- [PMID:41530860] | Li J, Li A, Ye C, Zhang L, Jiang M et al | Mol Neurodegener | 2026 | 0 |
| FOXF2 regulates pericyte-endothelial signaling required for vascular homeostasis [PMID:41680210] | Sun F, Zhao Y, Do J, Cheng P, Li E et al | Nat Commun | 2026 | 0 |
| Molecular Characterization of Biphasic Follicular Dendritic Cell Sarcoma. [PMID:41943444] | Hassan F, Boyle T, Palma J, Li J, Hussai | Appl Immunohistochem Mol Morph | 2026 | 0 |
| Immunological mechanisms and therapeutic approaches in pulmonary fibrosis. [PMID:41951242] | Nell LM, Hendriks RW, Wijsenbeek MS, Cor | Eur Respir Rev | 2026 | 0 |
| Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129] | Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu | Clinical & experimental ophtha | 2026 | 0 |
| Nicotinic acetylcholine receptor activation induces BACE1 transcription via the [PMID:38110001] | Nakano M, Tsuchida T, Mitsuishi Y, Nishi | Neurosci Res | 2024 | 0 |
| The influence of inhibiting or stimulating the expression of the α3 subunit of t [PMID:23201341] | Qi XL, Zhang XL, Ou-Yang K, Shan KR, Gua | Neurochem Int | 2013 | 0 |
| [Influence of inhibited α7 nicotinic acetylcholine receptor gene expression on t [PMID:23324234] | Ouyang K, Qi XL, Guan ZZ | Zhonghua Bing Li Xue Za Zhi | 2012 | 0 |
| Effects of galantamine on β-amyloid release and beta-site cleaving enzyme 1 expr [PMID:20600777] | Li Q, Wu D, Zhang L, Zhang Y | Exp Gerontol | 2010 | 0 |
| Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued b [PMID:20943921] | Wang H, Song L, Lee A, Laird F, Wong PC | J Neurosci | 2010 | 0 |