mechanism 1,896 words KG: ent-gene-e9e639fd 2026-03-31
kind:section:mechanismsevidence:strongmechanismsection:mechanismsstate:publishedtopic:causal-chaintopic:bin1topic:endosomestopic:tautopic:alzheimerstopic:genetics
Contents

BIN1→Endosomal Dysfunction→Tau Pathology→AD Causal Chain

🔬 Protein Info
Gene SymbolBIN1
Full NameBridging Integrator 1 (Amphiphysin 2)
Chromosome2q14.3
Functionis a gene located on chromosome 2q14.
Primary ExpressionCerebral cortex, Hippocampus, White matter, Cerebellum
Molecular Weight70 kDa
Exons20
PathwaysAutophagy, Complement, Endocytosis, proinflammatory activation
UniProt IDO00499
NCBI Gene ID274
Ensembl IDENSG00000136717
OMIM601248
GeneCardsBIN1
Human Protein AtlasBIN1
ProteinBAR domain adapter protein (O00499)
Associated DiseasesALS, ALZHEIMER, ALZHEIMER'S DISEASE
InteractionsG3BP1, CLU, CLUSTERIN, APOE, CD33, LRP1
KG Connections926 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (26)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (30)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (9)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

Knowledge Graph (4 edges)

ent-gene-e9e639fd data_in ad_genetic_risk_loci:BIN1
ent-gene-e9e639fd data_in benchmark_ot_ad_answer_key:BIN1
ad_genetic_risk_loci:BIN1 data_in ent-gene-e9e639fd
benchmark_ot_ad_answer_key:BIN1 data_in ent-gene-e9e639fd