Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB17 (Member RAS Oncogene Family 17) is a Rab GTPase involved in polarized trafficking, melanosome transport, and neuronal protein delivery.
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| Gene Symbol | RAB17 |
| Full Name | Member RAS Oncogene Family 17 |
| Chromosome | 2q37.2 |
| Function | encodes a member of the Rab GTPase family, which constitutes the largest family of small GTP-binding proteins involved in regulating intracellular membrane trafficking. |
| Subcellular Localization | and function in membrane trafficking pathways |
| Amino Acids | 213 aa |
| UniProt ID | [Q9H0T7](https://www.uniprot.org/uniprot/Q9H0T7) |
| Ensembl ID | ENSG00000124839 |
| GeneCards | RAB17 |
| Human Protein Atlas | RAB17 |
| GTP-bound state | Active, can interact with effector proteins |
| GDP-bound state | Inactive, cytosolic |
| GDI (GDP Dissociation Inhibitor) | Extracts GDP-bound RAB from membranes |
| GDF (GDI Displacement Factor) | Releases RAB from GDI |
| GAP (GTPase Activating Protein) | Inactivates RAB by stimulating GTP hydrolysis |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAB17["RAB17"]
neurodegeneration["neurodegeneration"]
RAB17 -->|"implicated_in"| neurodegeneration
style RAB17 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RAB17 in their description or question text
No additional research found