gene

RAB40B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB40B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

RAB40B is a Rab GTPase with SOCS box domain involved in endosomal trafficking, protein degradation, and neurodegenerative disease pathogenesis.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	RAB40B
Full Name	Member RAS Oncogene Family
Function	is a member of the Rab GTPase family characterized by the presence of a SOCS (Suppressor of Cytokine Signaling) box domain.
Primary Expression	neuronal tissues where it plays critical roles in endosomal trafficking, protein degradation pathways, and synaptic function
Subcellular Localization	and regulation of RAB40B is mediated through these GTPase regulatory proteins
Ensembl ID	ENSG00000120251
GeneCards	RAB40B
Human Protein Atlas	RAB40B
Active (GTP-bound) state	When bound to GTP, RAB40B can interact with downstream effectors and participate in vesicle targeting
Inactive (GDP-bound) state	GDP-bound RAB40B is sequestered by GDP Dissociation Inhibitors (GDIs), which prevent inappropriate effector interactions
GDFs (GDP Dissociation Factors)	These proteins catalyze GDP release, allowing GTP binding
Rabin8/RABIN8	A GEF that may activate RAB40B
RABP1 (Rabenosyn-5)	An effector involved in endosomal trafficking
ESCRT complex components	Proteins involved in multivesicular body formation
E3 ubiquitin ligases	Via the SOCS box domain
Associated Diseases	Parkinson's disease, Alzheimer's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RAB40B

gene · 1653 words

→

Pathway Diagram

graph TD
    RAB40B["RAB40B"]
    neurodegeneration["neurodegeneration"]
    RAB40B -->|"implicated_in"| neurodegeneration
    style RAB40B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity