gene

RPL17

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPL17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections
0Hypotheses
0Analyses
11Outgoing
0Incoming

Summary

RPL17 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, binds. Associated with ankylosing spondylitis, breast cancer, migraine. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRPL17
Full NameRibosomal Protein L17
Chromosome18q21.1
FunctionRPL17 encodes Ribosomal Protein L17 (also known as L23), a component of the large (60S) ribosomal subunit.
Primary ExpressionAD brain [@hernandezortega2016] - RPL17 shows altered expression in AD temporal lobe - Global translation deficits in AD neurons correlate with cognit
UniProt IDP18621
NCBI Gene ID6169
GeneCardsRPL17
Human Protein AtlasRPL17
Associated Diseasesankylosing spondylitis, migraine, osteoporosis
InteractionsYBX1
KG Connections11 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: RPL17 — AlphaFold P18621 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

RPL17 — Ribosomal Protein L17

gene · 1726 words

RPL4 — Ribosomal Protein L4

gene · 1767 words

Migraine

disease · 1666 words

APOA1 Gene

gene · 748 words

Genes

index · 271 words

Pathway Diagram

graph TD
    RPL17["<b>RPL17</b>"]
    HCV["HCV"]
    RPL17 -->|"binds"| HCV
    YBX1["YBX1"]
    RPL17 -->|"interacts with"| YBX1
    STAT5b["STAT5b"]
    RPL17 -->|"binds"| STAT5b
    APOA1["APOA1"]
    RPL17 -->|"regulates"| APOA1
    intestinal_stem_cells["intestinal stem cells"]
    RPL17 -->|"participates in"| intestinal_stem_cells
    n_5_8S_rRNA["5.8S rRNA"]
    RPL17 -->|"regulates"| n_5_8S_rRNA
    breast_cancer{"breast cancer"}
    RPL17 -->|"regulates"| breast_cancer
    A_["Abeta"]
    RPL17 -->|"associated with"| A_
    ankylosing_spondylitis{"ankylosing spondylitis"}
    RPL17 -->|"associated with"| ankylosing_spondylitis
    osteoporosis{"osteoporosis"}
    RPL17 -->|"associated with"| osteoporosis
    migraine{"migraine"}
    RPL17 -->|"associated with"| migraine
    neurodegeneration["neurodegeneration"]
    RPL17 -->|"implicated in"| neurodegeneration
    style RPL17 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

TargetRelationTypeStr
HCVbindsentity0.80
YBX1interacts_withprotein0.80
STAT5bbindsprotein0.80
APOA1regulatesgene0.80
intestinal stem cellsparticipates_incell_type0.80

Incoming (0)

SourceRelationTypeStr
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found