Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPL17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RPL17 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, binds. Associated with ankylosing spondylitis, breast cancer, migraine. Connected to 12 entities in the SciDEX knowledge graph.
| Gene Symbol | RPL17 |
| Full Name | Ribosomal Protein L17 |
| Chromosome | 18q21.1 |
| Function | RPL17 encodes Ribosomal Protein L17 (also known as L23), a component of the large (60S) ribosomal subunit. |
| Primary Expression | AD brain [@hernandezortega2016] - RPL17 shows altered expression in AD temporal lobe - Global translation deficits in AD neurons correlate with cognit |
| UniProt ID | P18621 |
| NCBI Gene ID | 6169 |
| GeneCards | RPL17 |
| Human Protein Atlas | RPL17 |
| Associated Diseases | ankylosing spondylitis, migraine, osteoporosis |
| Interactions | YBX1 |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RPL17["<b>RPL17</b>"]
HCV["HCV"]
RPL17 -->|"binds"| HCV
YBX1["YBX1"]
RPL17 -->|"interacts with"| YBX1
STAT5b["STAT5b"]
RPL17 -->|"binds"| STAT5b
APOA1["APOA1"]
RPL17 -->|"regulates"| APOA1
intestinal_stem_cells["intestinal stem cells"]
RPL17 -->|"participates in"| intestinal_stem_cells
n_5_8S_rRNA["5.8S rRNA"]
RPL17 -->|"regulates"| n_5_8S_rRNA
breast_cancer{"breast cancer"}
RPL17 -->|"regulates"| breast_cancer
A_["Abeta"]
RPL17 -->|"associated with"| A_
ankylosing_spondylitis{"ankylosing spondylitis"}
RPL17 -->|"associated with"| ankylosing_spondylitis
osteoporosis{"osteoporosis"}
RPL17 -->|"associated with"| osteoporosis
migraine{"migraine"}
RPL17 -->|"associated with"| migraine
neurodegeneration["neurodegeneration"]
RPL17 -->|"implicated in"| neurodegeneration
style RPL17 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| HCV | binds | entity | 0.80 |
| YBX1 | interacts_with | protein | 0.80 |
| STAT5b | binds | protein | 0.80 |
| APOA1 | regulates | gene | 0.80 |
| intestinal stem cells | participates_in | cell_type | 0.80 |
| 5.8S rRNA | regulates | entity | 0.80 |
| breast cancer | regulates | disease | 0.80 |
| ankylosing spondylitis | associated_with | disease | 0.70 |
| osteoporosis | associated_with | disease | 0.70 |
| migraine | associated_with | disease | 0.70 |
| Aβ | associated_with | chemical | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||