gene

YBX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YBX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

148Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

YBX1 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Als, Cancer, Carcinoma. Connected to 76 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolYBX1
Full NameY-Box Binding Protein 1
Chromosome1p34.2
Functionis a multifunctional DNA- and RNA-binding protein that plays critical roles in transcriptional regulation, mRNA splicing, translation, and stress response.
Primary Expressionthe CNS: - High expression in neurons throughout the brain - Present in astrocytes and [microglia](/c
Subcellular Localizationand function
Molecular Weight36 kDa
Amino Acids70 aa
PathwaysGlycolysis, Multidrug Resistance, Nf-Κb, Wnt, mRNA Stability
UniProt IDP62962
NCBI Gene ID5102
Ensembl IDENSG00000165996
OMIM113703
GeneCardsYBX1
Human Protein AtlasYBX1
Associated DiseasesCancer
Known Drugs/Compoundsm5C-modified mRNAs, m5C, SU056
InteractionsELAVL1, TCF3, CAT, PEX1, SPP1, G3BP1
KG Connections148 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: YBX1 — AlphaFold P62962 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Canonical Page

YBX1 Gene

gene · 915 words

NSUN2 Gene

gene · 3064 words

TLP (TROVE1) Protein

protein · 2843 words

herc5

gene · 2524 words

CYP27B1 — Vitamin D 1-alpha Hydroxylase

gene · 1954 words

WNT7B Gene - Wnt Family Member 7B

gene · 1913 words

Pathway Diagram

graph TD
    YBX1["<b>YBX1</b>"]
    LRP1["LRP1"]
    YBX1 -->|"activates"| LRP1
    YBX1 -->|"regulates"| LRP1
    Cancer{"Cancer"}
    YBX1 -->|"activates"| Cancer
    Carcinoma{"Carcinoma"}
    YBX1 -->|"activates"| Carcinoma
    Tumor{"Tumor"}
    YBX1 -->|"activates"| Tumor
    Ms{"Ms"}
    YBX1 -->|"activates"| Ms
    YBX1 -->|"therapeutic target"| Carcinoma
    Als{"Als"}
    YBX1 -->|"regulates"| Als
    YBX1 -->|"regulates"| Tumor
    YBX1 -->|"associated with"| Cancer
    YBX1 -->|"interacts with"| Cancer
    DRUG_RESISTANCE["DRUG_RESISTANCE"]
    YBX1 -->|"activates"| DRUG_RESISTANCE
    RPL17["RPL17"]
    RPL17 -->|"interacts with"| YBX1
    SU056["SU056"]
    SU056 -->|"inhibits"| YBX1
    NSUN2["NSUN2"]
    NSUN2 -->|"therapeutic target"| YBX1
    LRP1 -->|"activates"| YBX1
    TCF3["TCF3"]
    TCF3 -->|"activates"| YBX1
    RRM1["RRM1"]
    RRM1 -->|"therapeutic target"| YBX1
    GAIN["GAIN"]
    GAIN -->|"activates"| YBX1
    GENES["GENES"]
    GENES -->|"activates"| YBX1
    DNA["DNA"]
    DNA -->|"activates"| YBX1
    G3BP1["G3BP1"]
    G3BP1 -->|"activates"| YBX1
    RECQL4["RECQL4"]
    RECQL4 -->|"activates"| YBX1
    ELAVL1["ELAVL1"]
    ELAVL1 -->|"interacts with"| YBX1
    style YBX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (74)

TargetRelationTypeStr
m5C-modified mRNAsbindscompound0.95
m5Cbindscompound0.95
Bladder Cancerdrivesdisease0.90
Yap Mrna Stabilitypromotesprocess0.90
mRNA Stabilityregulatesprocess0.90

Incoming (74)

SourceRelationTypeStr
ALYREFinteracts_withgene0.85
RPL17interacts_withgene0.80
SU056inhibitsdrug0.72
GENESactivatesgene0.70
ELAVL1therapeutic_targetentity0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found