Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about YBX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
YBX1 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Als, Cancer, Carcinoma. Connected to 76 entities in the SciDEX knowledge graph.
| Gene Symbol | YBX1 |
| Full Name | Y-Box Binding Protein 1 |
| Chromosome | 1p34.2 |
| Function | is a multifunctional DNA- and RNA-binding protein that plays critical roles in transcriptional regulation, mRNA splicing, translation, and stress response. |
| Primary Expression | the CNS: - High expression in neurons throughout the brain - Present in astrocytes and [microglia](/c |
| Subcellular Localization | and function |
| Molecular Weight | 36 kDa |
| Amino Acids | 70 aa |
| Pathways | Glycolysis, Multidrug Resistance, Nf-Κb, Wnt, mRNA Stability |
| UniProt ID | P62962 |
| NCBI Gene ID | 5102 |
| Ensembl ID | ENSG00000165996 |
| OMIM | 113703 |
| GeneCards | YBX1 |
| Human Protein Atlas | YBX1 |
| Associated Diseases | Cancer |
| Known Drugs/Compounds | m5C-modified mRNAs, m5C, SU056 |
| Interactions | ELAVL1, TCF3, CAT, PEX1, SPP1, G3BP1 |
| KG Connections | 148 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
YBX1["<b>YBX1</b>"]
LRP1["LRP1"]
YBX1 -->|"activates"| LRP1
YBX1 -->|"regulates"| LRP1
Cancer{"Cancer"}
YBX1 -->|"activates"| Cancer
Carcinoma{"Carcinoma"}
YBX1 -->|"activates"| Carcinoma
Tumor{"Tumor"}
YBX1 -->|"activates"| Tumor
Ms{"Ms"}
YBX1 -->|"activates"| Ms
YBX1 -->|"therapeutic target"| Carcinoma
Als{"Als"}
YBX1 -->|"regulates"| Als
YBX1 -->|"regulates"| Tumor
YBX1 -->|"associated with"| Cancer
YBX1 -->|"interacts with"| Cancer
DRUG_RESISTANCE["DRUG_RESISTANCE"]
YBX1 -->|"activates"| DRUG_RESISTANCE
RPL17["RPL17"]
RPL17 -->|"interacts with"| YBX1
SU056["SU056"]
SU056 -->|"inhibits"| YBX1
NSUN2["NSUN2"]
NSUN2 -->|"therapeutic target"| YBX1
LRP1 -->|"activates"| YBX1
TCF3["TCF3"]
TCF3 -->|"activates"| YBX1
RRM1["RRM1"]
RRM1 -->|"therapeutic target"| YBX1
GAIN["GAIN"]
GAIN -->|"activates"| YBX1
GENES["GENES"]
GENES -->|"activates"| YBX1
DNA["DNA"]
DNA -->|"activates"| YBX1
G3BP1["G3BP1"]
G3BP1 -->|"activates"| YBX1
RECQL4["RECQL4"]
RECQL4 -->|"activates"| YBX1
ELAVL1["ELAVL1"]
ELAVL1 -->|"interacts with"| YBX1
style YBX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| m5C-modified mRNAs | binds | compound | 0.95 |
| m5C | binds | compound | 0.95 |
| Bladder Cancer | drives | disease | 0.90 |
| Yap Mrna Stability | promotes | process | 0.90 |
| mRNA Stability | regulates | process | 0.90 |
| Yap Mrna | binds | biomarker | 0.88 |
| Urothelial Carcinoma of Bladder | contributes_to | disease | 0.88 |
| HDGF | upregulates | gene | 0.85 |
| Bladder Cancer | biomarker_for | disease | 0.80 |
| Cancer | activates | disease | 0.75 |
| Carcinoma | activates | disease | 0.75 |
| Tumor | activates | disease | 0.75 |
| LRP1 | activates | protein | 0.72 |
| LRP1 | regulates | protein | 0.72 |
| Ms | activates | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Pancreatic Cancer | activates | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| DRUG_RESISTANCE | activates | phenotype | 0.64 |
| ELAVL1 | interacts_with | gene | 0.60 |
| TCF3 | activates | gene | 0.60 |
| CAT | inhibits | gene | 0.60 |
| PEX1 | inhibits | gene | 0.60 |
| SPP1 | activates | gene | 0.60 |
| G3BP1 | activates | gene | 0.60 |
| MECP2 | therapeutic_target | gene | 0.60 |
| HSPA1A | therapeutic_target | gene | 0.60 |
| SYNCRIP | therapeutic_target | gene | 0.60 |
| G3BP1 | therapeutic_target | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| MYC | therapeutic_target | gene | 0.60 |
| HSPA1A | activates | gene | 0.60 |
| NSUN2 | causes | gene | 0.60 |
| NSUN2 | therapeutic_target | gene | 0.60 |
| JUN | activates | gene | 0.60 |
| HERC5 | regulates | gene | 0.60 |
| Nf-Κb | activates | pathway | 0.60 |
| NF-ΚB | activates | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| NATURAL COMPOUNDS | therapeutic_target | gene | 0.60 |
| CANCER | interacts_with | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| Apoptosis | therapeutic_target | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALYREF | interacts_with | gene | 0.85 |
| RPL17 | interacts_with | gene | 0.80 |
| SU056 | inhibits | drug | 0.72 |
| GENES | activates | gene | 0.70 |
| ELAVL1 | therapeutic_target | entity | 0.60 |
| NSUN2 | regulates | entity | 0.60 |
| CANCER | inhibits | entity | 0.60 |
| NSUN2 | therapeutic_target | gene | 0.60 |
| LRP1 | activates | gene | 0.60 |
| TCF3 | activates | gene | 0.60 |
| GAIN | activates | gene | 0.60 |
| G3BP1 | activates | gene | 0.60 |
| RECQL4 | activates | gene | 0.60 |
| ELAVL1 | interacts_with | gene | 0.60 |
| TCF3 | therapeutic_target | gene | 0.60 |
| PEX3 | inhibits | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| IGF2BP1 | therapeutic_target | gene | 0.60 |
| EWSR1 | therapeutic_target | gene | 0.60 |
| NSUN2 | causes | gene | 0.60 |
| JAK2 | regulates | gene | 0.60 |
| CD44 | therapeutic_target | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| ABCB1 | activates | gene | 0.60 |
| BCL2 | therapeutic_target | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| PGK1 | activates | gene | 0.60 |
| WNT7B | activates | gene | 0.60 |
| G3BP1 | interacts_with | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| JAK2 | inhibits | gene | 0.60 |
| JAK2 | activates | gene | 0.60 |
| BECN1 | targets | gene | 0.60 |
| CYP27B1 | targets | gene | 0.60 |
| GCLC | targets | gene | 0.60 |
| PCBP2 | targets | gene | 0.60 |
| PEX13 | targets | gene | 0.60 |
| PPP1CA | targets | gene | 0.60 |
| VPS29 | targets | gene | 0.60 |
| VPS35 | targets | gene | 0.60 |
| NSUN2 | interacts_with | gene | 0.60 |
| AGO2 | activates | gene | 0.60 |
| CTGF | activates | gene | 0.60 |
| MMP2 | activates | gene | 0.60 |
| MMP9 | activates | gene | 0.60 |
| NSUN2 | activates | gene | 0.60 |
| ALYREF | activates | gene | 0.60 |
| RRM1 | therapeutic_target | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| FLAVONOIDS | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||