disease

migraine

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about migraine: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

235Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

Disease Info

HTR1A	Autoreceptor (somatodendritic) controlling firing rate
HTR1B	Autoreceptor (terminal) inhibiting release
HTR2A	Postsynaptic excitatory receptor
HTR2C	Postsynaptic receptor modulating pain and mood
HTR7	Postsynaptic excitatory receptor in circadian regulation
Associated Genes	EPHA5, RPL17
KG Connections	10 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Serotonergic Raphe Neurons in Migraine

cell · 811 words

→

Pathway Diagram

graph TD
    MIGRAINE["MIGRAINE"]
    Oxidative_stress["Oxidative stress"] -->|"causes"| MIGRAINE
    Cerebral_energy_deficiency["Cerebral energy deficiency"] -->|"causes"| MIGRAINE
    CCL3["CCL3"] -->|"activates"| MIGRAINE
    C1Q["C1Q"] -->|"activates"| MIGRAINE
    CHR2["CHR2"] -->|"activates"| MIGRAINE
    TNF["TNF"] -->|"regulates"| MIGRAINE
    GENES["GENES"] -->|"activates"| MIGRAINE
    MICROGLIA["MICROGLIA"] -->|"regulates"| MIGRAINE
    ASTROCYTES["ASTROCYTES"] -->|"regulates"| MIGRAINE
    IL_6["IL-6"] -->|"regulates"| MIGRAINE

Outgoing (75)

Target	Relation	Type	Str
Inflammation	activates	disease	0.65
NEURODEGENERATION	interacts_with	disease	0.65
CHOLESTEROL	regulates	phenotype	0.65
Blood-Brain Barrier	associated_with	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Notch	contributes_to	pathway	0.60
unfolded protein response	involves	pathway	0.60
MULTIPLE SCLEROSIS	activates	disease	0.60
nitric oxide	disrupts	neurotransmitter	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
SCHIZOPHRENIA	inhibits	entity	0.60
neurons	affects	cell_type	0.60
ferroptosis	involves	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
Angiogenesis	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
NEURODEGENERATION	causes	disease	0.60
Blood-Brain Barrier	activates	pathway	0.60
Neutrophil	associated_with	cell_type	0.55
Dendritic Cell	associated_with	cell_type	0.55
Cell Cycle	regulates	pathway	0.55
Ferroptosis	regulates	pathway	0.55
Calcium Signaling	regulates	pathway	0.55
Neurodegeneration	activates	disease	0.55
Alzheimer	activates	disease	0.55
Glaucoma	activates	disease	0.55
Amyloid	activates	pathway	0.55
Neuroinflammatory	regulates	pathway	0.55
Neuron	activates	cell_type	0.55
Calcium Signaling	associated_with	pathway	0.55
Cell Cycle	associated_with	pathway	0.55
Macrophage	associated_with	cell_type	0.55
Circadian Rhythm	therapeutic_target	pathway	0.55
Inflammasome	activates	pathway	0.55
Autism	associated_with	disease	0.55
Parkinson	associated_with	disease	0.55
Multiple Sclerosis	associated_with	disease	0.55
Alzheimer	therapeutic_target	disease	0.55
Astrocyte	regulates	cell_type	0.55
Inflammation	associated_with	disease	0.55
Dementia	contributes_to	disease	0.55
Microglia	activates	cell_type	0.55
Ms	associated_with	disease	0.55
Circadian Rhythm	activates	pathway	0.55
Cholesterol	activates	pathway	0.55
Huntington	associated_with	disease	0.55
METFORMIN	inhibits	concept	0.50
inflammation	associated_with	pathway	0.50
oxidative stress	associated_with	phenotype	0.50

Incoming (160)

Source	Relation	Type	Str
mitochondrial dysfunction	contributes_to	mechanism	0.90
EPHA5	associated_with	gene	0.80
INFLAMMATION	activates	gene	0.75
Niacin	treats	drug	0.75
RPL17	associated_with	gene	0.70
Oxidative stress	causes	process	0.70
Cerebral energy deficiency	causes	process	0.70
Cerebral energy metabolism	associated_with	process	0.70
MITOPHAGY	associated_with	gene	0.65
TRPA1	inhibits	gene	0.65
SRC	regulates	gene	0.65
SCN8A	inhibits	gene	0.65
AKT1	inhibits	gene	0.65
TRPM3	inhibits	gene	0.65
CREBBP	inhibits	gene	0.65
ASTROCYTES	contributes_to	gene	0.65
NF-ΚB	activates	gene	0.65
ASTROCYTE	contributes_to	gene	0.65
CYTOKINES	activates	gene	0.65
CD4	regulates	gene	0.65
DEPRESSION	therapeutic_target	gene	0.65
BRAIN INJURY	therapeutic_target	gene	0.65
STROKE	therapeutic_target	gene	0.65
PARKINSON'S DISEASE	therapeutic_target	gene	0.65
CIRCADIAN RHYTHM	therapeutic_target	gene	0.65
CLOCK	therapeutic_target	gene	0.65
NEUROINFLAMMATION	inhibits	gene	0.65
NLRP3	activates	gene	0.65
TNC	activates	gene	0.65
SYK	inhibits	gene	0.65
TREM2	inhibits	gene	0.65
NAD	activates	gene	0.65
GPR109A	activates	gene	0.65
LDL	activates	gene	0.65
GABA-A	activates	gene	0.65
CHR2	activates	gene	0.65
TNF	regulates	gene	0.65
OVERVIEW	associated_with	gene	0.65
ALZHEIMER	associated_with	gene	0.65
DEPRESSION	associated_with	gene	0.65
PARKINSON'S DISEASE	associated_with	gene	0.65
PARKINSON	associated_with	gene	0.65
EPILEPSY	associated_with	gene	0.65
HUNTINGTON'S DISEASE	associated_with	gene	0.65
HUNTINGTON	associated_with	gene	0.65
APOPTOSIS	activates	gene	0.65
GABA	activates	gene	0.65
STROKE	associated_with	gene	0.65
GENES	activates	gene	0.65
MICROGLIA	regulates	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning migraine in their description or question text

No additional research found