gene

APOA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APOA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

297Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

APOA1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, inhibits. Associated with AD, ALS, AMI. Connected to 93 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	APOA1
Full Name	Apolipoprotein A1
Chromosome	Chr11q23.3
Function	The APOA1 gene encodes Apolipoprotein A1, the primary protein component of high-density lipoprotein (HDL) particles.
UniProt ID	P02647
NCBI Gene ID	335
Ensembl ID	ENSG00000118137
OMIM	107680
GeneCards	APOA1
Human Protein Atlas	APOA1
Associated Diseases	AD, ALS, AMI, ARM, Alzheimer
Interactions	ULK1, ATG5, EIF4EBP1, LC3, MTOR, ABCG1
KG Connections	297 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: APOA1 — AlphaFold P02647 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    APOA1["APOA1"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    APOA1["APOA1"] -->|"interacts"| Als["Als"]
    APOA1["APOA1"] -->|"activates"| Ms["Ms"]
    APOA1["APOA1"] -->|"activates"| Atherosclerosis_1["Atherosclerosis"]
    APOA1["APOA1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    APOA1["APOA1"] -->|"therapeutic target"| Als_2["Als"]
    RPL17["RPL17"] -->|"regulates"| APOA1["APOA1"]
    ACTB["ACTB"] -->|"interacts"| APOA1["APOA1"]
    P2RY12["P2RY12"] -.->|"inhibits"| APOA1["APOA1"]
    SOAT1["SOAT1"] -->|"activates"| APOA1["APOA1"]
    style APOA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (209)

Target	Relation	Type	Str
Blastocyst Formation	involved_in	process	0.90
Cell Differentiation	involved_in	process	0.90
LIPID METABOLISM	involved_in	entity	0.85
Atherosclerosis	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Ms	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Carcinoma	biomarker_for	disease	0.65
Ms	associated_with	disease	0.65
Tumor	biomarker_for	disease	0.65
ALS	interacts_with	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Als	activates	disease	0.65
Atherosclerosis	transports	disease	0.65
Alzheimer	transports	disease	0.65
ALS	transports	disease	0.65
Atherosclerosis	degrades	disease	0.65
Alzheimer	degrades	disease	0.65
Als	degrades	disease	0.65
ULK1	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
EIF4EBP1	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MTOR	inhibits	gene	0.60
ABCG1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
ABCA1	interacts_with	gene	0.60
APOE	inhibits	gene	0.60
LOX	interacts_with	gene	0.60
CD36	activates	gene	0.60
PLIN2	activates	gene	0.60
NR1H3	activates	gene	0.60
P2RY12	inhibits	gene	0.60
SOAT1	activates	gene	0.60
DGAT1	activates	gene	0.60
PPARGC1A	therapeutic_target	gene	0.60
ESR1	therapeutic_target	gene	0.60
SERPINE1	therapeutic_target	gene	0.60
IGF1	therapeutic_target	gene	0.60
PON1	therapeutic_target	gene	0.60
ATG5	activates	entity	0.60
EIF4EBP1	activates	entity	0.60
LC3	activates	entity	0.60
LOX	activates	entity	0.60

Incoming (88)

Source	Relation	Type	Str
RPL17	regulates	gene	0.80
ACTB	interacts_with	gene	0.60
P2RY12	inhibits	gene	0.60
SOAT1	activates	gene	0.60
DGAT1	activates	gene	0.60
ATG5	interacts_with	gene	0.60
PI3K	inhibits	gene	0.60
LOX	interacts_with	gene	0.60
MTOR	inhibits	gene	0.60
AKT	inhibits	gene	0.60
SQSTM1	interacts_with	gene	0.60
EIF4EBP1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
CD36	activates	gene	0.60
ABCA1	interacts_with	gene	0.60
PON1	therapeutic_target	gene	0.60
IGF1	therapeutic_target	gene	0.60
SERPINE1	therapeutic_target	gene	0.60
APOE4	associated_with	gene	0.60
APOA2	associated_with	gene	0.60
APOC2	associated_with	gene	0.60
MCC	associated_with	gene	0.60
CAT	associated_with	gene	0.60
LC3	interacts_with	gene	0.60
APOE	inhibits	gene	0.60
ULK1	interacts_with	gene	0.60
ABCG1	interacts_with	gene	0.60
PLIN2	activates	gene	0.60
PPARGC1A	therapeutic_target	gene	0.60
ABCA1	activates	entity	0.60
ABCG1	activates	entity	0.60
ACTB	activates	entity	0.60
NR1H3	activates	gene	0.60
LRP8	activates	gene	0.60
TLR4	activates	gene	0.60
APOE	transports	gene	0.60
NCSTN	transports	gene	0.60
PSEN2	transports	gene	0.60
LIPA	transports	gene	0.60
LDLR	transports	gene	0.60
ABCA1	transports	gene	0.60
GSK3B	transports	gene	0.60
LRP8	transports	gene	0.60
SREBF1	degrades	gene	0.60
CYP46A1	activates	gene	0.60
PSEN1	degrades	gene	0.60
GSK3B	degrades	gene	0.60
LRP1	activates	gene	0.60
NCSTN	degrades	gene	0.60
LDLR	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

APOA1

Understanding Entity Pages

Summary

Wiki Pages (21)

APOA1 Gene

TREM2→Microglial Dysfunction→Alzheimer's Disease Causal Chain

TREM2-SYK Signaling Cascade

APOC1 Gene — Apolipoprotein C-I

PON1 — Paraoxonase 1

ATG5 — Autophagy Related 5

PON3 — Paraoxonase 3

DGAT1 — Diacylglycerol O-Acyltransferase 1

ABCA1 Protein

P2RY12 Gene

Transdiagnostic Proteomic Changes in Neurodegeneration

P2Y12 Receptor Protein

LXR Protein (Liver X Receptor)

ARH Gene

Protein Families & Clusters

APOC2 Protein

APOB Protein

SCARB1 Protein (Scavenger Receptor Class B Type 1)

APOB Gene