Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPS15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RPS15 |
| Chromosome | 19p13.2 |
| Function | mRNA decoding: The decoding center where codon-anticodon pairing is verified |
| Molecular Weight | 17.2 kDa |
| Amino Acids | 145 aa |
| Ensembl ID | ENSG00000149091 |
| GeneCards | RPS15 |
| Human Protein Atlas | RPS15 |
| RNA-binding domain | Facilitates codon-anticodon base pairing |
| RPS19-binding site | Forms heterodimer with RPS19 for ribosome assembly |
| Nucleolar localization signal | Targets protein to nucleolus for ribosome biogenesis |
| Somatic mutations | RPS15 mutations identified in sporadic ALS motor neurons |
| Ribosomal dysfunction | Global translation impairment in ALS |
| Nucleolar stress | Nucleolar alterations in ALS postmortem tissue |
| p53 activation | Ribosomal stress may contribute to p53-dependent cell death |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RPS15["RPS15"]
neurodegeneration["neurodegeneration"]
RPS15 -->|"implicated_in"| neurodegeneration
style RPS15 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RPS15 in their description or question text
No additional research found