Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Resilience: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Selective Vulnerability | protects_against | phenotype | 0.80 |
| Neurodegeneration | protects_against | process | 0.80 |
| Alzheimer's Disease | protects_against | disease | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| DPP6-linked neuronal regulatory networks controlling synapti | 0.626 | neurodegeneration | DPP6 GWAS Signal: Cell-Type Regulatory N |
| NOMO1-Mediated Neuronal Resilience Enhancement | 0.584 | neurodegeneration | Gene expression changes in aging mouse b |
| CX3CR1-Negative Trem2-High Microglial Subset Mediates Female | 0.570 | neuroinflammation | How do regional, age, and sex-dependent |
| DNMT1 Compensation Window During Synaptic Resilience Phase | 0.528 | neurodegeneration | What is the optimal therapeutic window d |
| Propionate may outperform acetate or butyrate at physiologic | 0.440 | neurodegeneration | Do physiological concentrations of SCFAs |
| Ethnic and Metabolic Epigenetic Clock Divergence Explains Di | 0.376 | - | Epigenetic clocks as biomarkers for Alzh |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Mesothelin Promotes Acute Myeloid Leukemia Progression through LYN-dependent Sig [PMID:41866035] | Faust JR, Hamill D, Kolb EA, Stevens AM, | J Biol Chem | 2026 | 0 |
| Epigenetic/circadian clocks and PCOS. [PMID:38600622] | Vatier C, Christin-Maitre S | Hum Reprod | 2024 | 0 |
| The role of cellular senescence in neurodegenerative diseases. [PMID:38744709] | Wang Y, Kuca K, You L, Nepovimova E, Heg | Archives of toxicology | 2024 | 0 |
| The role of cellular senescence in neurodegenerative diseases. [PMID:38744709] | Wang Y, Kuca K, You L, Nepovimova E, Heg | Archives of toxicology | 2024 | 0 |
| Exercise therapy to prevent and treat Alzheimer's disease. [PMID:37600508] | ["Pahlavani H"] | Frontiers in aging neuroscienc | 2023 | 0 |
| Exercise therapy to prevent and treat Alzheimer's disease. [PMID:37600508] | ["Pahlavani H"] | Frontiers in aging neuroscienc | 2023 | 0 |
| Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease. [PMID:34239348] | Zhang, Wei, Zhao, Ma, Jiang et al. | International journal of biolo | 2022 | 0 |
| Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive dec [PMID:35130907] | ["Liu Sen", "Fan Min", "Xu Jing-Xian", " | Journal of neuroinflammation | 2022 | 0 |
| Metabolic programs tailor T cell immunity in viral infection, cancer, and aging. [PMID:35235773] | Møller SH, Hsueh PC, Yu YR | Cell Metab | 2022 | 0 |
| Epigenetic clock: A promising biomarker and practical tool in aging. [PMID:36206857] | Duan R, Fu Q, Sun Y | Ageing Res Rev | 2022 | 0 |
| DNA methylation GrimAge version 2. [PMID:36516495] | Lu AT, Binder AM, Zhang J | Aging (Albany NY) | 2022 | 0 |
| Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease. [PMID:34239348] | Unknown | International journal of biolo | 2022 | 0 |
| Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive dec [PMID:35130907] | ["Liu Sen", "Fan Min", "Xu Jing-Xian", " | Journal of neuroinflammation | 2022 | 0 |
| A systematic review of biological, social and environmental factors associated w [PMID:33930583] | Oblak L, van der Zaag J, Higgins-Chen AT | Ageing Res Rev | 2021 | 0 |
| Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer [PMID:34116706] | Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, | Journal of neuroinflammation | 2021 | 0 |
| Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer [PMID:34116706] | Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, | Journal of neuroinflammation | 2021 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Resilience in their description or question text