gene

KLF4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KLF4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

247Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

KLF4 (Kruppel-Like Factor 4) is a zinc-finger transcription factor essential for cellular reprogramming, neuroprotection, and neural stem cell maintenance, with implications for Alzheimer's and Parkinson's disease therapy.

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🧬 Gene Info

Gene Symbol	KLF4
Full Name	Kruppel-Like Factor 4
Chromosome	9q31.2
Protein Type	Transcription Factor
Function	Cell cycle control: Represses proliferation genes (c-Myc, cyclin D1) while activating cell cycle inhibitors (p21, p27)
Primary Expression	High in brain, GI tract, endothelial cells
Amino Acids	483 aa
Pathways	Akt, Amyloid, Epigenetic, Neurogenesis, Nf-Kb
UniProt ID	O43474
NCBI Gene ID	9312
Ensembl ID	ENSG00000109576
OMIM	602253
GeneCards	KLF4
Human Protein Atlas	KLF4
Protein Class	C2H2 zinc-finger transcription factor
Associated Diseases	Atherosclerosis, Inflammation, Ms, Pluripotency, Senescence, Stroke
Interactions	POU5F1, SOX2, P38, JUND, JUN, OCT4
KG Connections	247 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KLF4 — AlphaFold O43474 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    KLF4["KLF4"] -->|"regulates"| Ms["Ms"]
    KLF4["KLF4"] -->|"regulates"| Inflammation["Inflammation"]
    KLF4["KLF4"] -->|"activates"| Cancer["Cancer"]
    KLF4["KLF4"] -->|"activates"| Tumor["Tumor"]
    KLF4["KLF4"] -->|"associated with"| Stroke["Stroke"]
    KLF4["KLF4"] -->|"associated with"| Ms["Ms"]
    KLF4["KLF4"] -->|"associated with"| Atherosclerosis["Atherosclerosis"]
    KLF4["KLF4"] -->|"expressed in"| Aging["Aging"]
    KLF4["KLF4"] -.->|"inhibits"| Ms["Ms"]
    KLF4["KLF4"] -->|"biomarker for"| Aging["Aging"]
    KLF4["KLF4"] -->|"activates"| Senescence["Senescence"]
    KLF4["KLF4"] -->|"activates"| Cardiovascular["Cardiovascular"]
    style KLF4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
    style Atherosclerosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Senescence fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (162)

Target	Relation	Type	Str
ATP2A3	activates	gene	0.95
ATP2A3	binds	gene	0.95
iPSC Reprogramming	involved_in	process	0.95
BIG1	regulates	gene	0.95
Pluripotency	activates	phenotype	0.90
Pluripotency	associated_with	phenotype	0.90
Embryonic Stem Cells	expressed_in	cell_type	0.90
Pluripotency	promotes	process	0.90
Transcription	regulates	process	0.85
Cellular Senescence	associated_with	process	0.85
Neuro-inflammation	mediates	process	0.80
Resilience	downregulates	phenotype	0.75
Tumor	activates	disease	0.75
Aging	expressed_in	disease	0.75
SOX2	regulates	gene	0.70
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	activates	disease	0.65
Stroke	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Aging	biomarker_for	disease	0.65
Senescence	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Aging	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Dementia	regulates	disease	0.65
ALS	regulates	disease	0.65
POU5F1	activates	gene	0.60
SOX2	activates	gene	0.60
P38	activates	gene	0.60
HSPA1A	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
NCF2	associated_with	gene	0.60
JUND	inhibits	gene	0.60
JUN	inhibits	gene	0.60
GAIN	regulates	gene	0.60
TNF	regulates	gene	0.60
PI3K	regulates	gene	0.60

Incoming (85)

Source	Relation	Type	Str
SOX2	interacts_with	gene	0.90
PI3K	therapeutic_target	gene	0.70
OCT4	regulates	gene	0.70
AGING	expressed_in	gene	0.70
SOX2	activates	gene	0.60
POU5F1	activates	gene	0.60
TNF	regulates	gene	0.60
GAIN	regulates	gene	0.60
AKT	regulates	gene	0.60
PI3K	regulates	gene	0.60
DUSP9	activates	gene	0.60
FOXO3	activates	gene	0.60
FOS	associated_with	gene	0.60
MYC	expressed_in	gene	0.60
SOX2	expressed_in	gene	0.60
FOS	inhibits	gene	0.60
RELA	inhibits	gene	0.60
MYC	inhibits	gene	0.60
AKT	therapeutic_target	gene	0.60
OCT4	activates	gene	0.60
OCT4	biomarker_for	gene	0.60
MYC	biomarker_for	gene	0.60
SOX2	biomarker_for	gene	0.60
DNMT3A	activates	gene	0.60
SOX2	regulates	gene	0.60
CLOCK	associated_with	gene	0.60
PPAR	therapeutic_target	gene	0.60
ARG1	activates	gene	0.60
TNF	activates	gene	0.60
NOS2	activates	gene	0.60
SQSTM1	activates	gene	0.60
ATG7	activates	gene	0.60
PPARG	activates	gene	0.60
PARKIN	regulates	gene	0.60
PINK1	regulates	gene	0.60
LC3	regulates	gene	0.60
GFAP	activates	gene	0.60
TAU	regulates	gene	0.60
BIG1	activates	gene	0.60
BIG1	regulates	gene	0.60
DEPTOR	regulates	gene	0.60
DNA	activates	gene	0.60
ERK	activates	gene	0.60
HIF1	activates	gene	0.60
MIRNAS	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
GENES	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KLF4

Understanding Entity Pages

Summary

Wiki Pages (21)

KLF4 Gene

Cellular Reprogramming Therapies for Neurodegeneration

TGF-β Signaling in Parkinson's Disease

Longevity and Rejuvenation Therapies Landscape

N-of-1 and Personalized Clinical Trial Design for CBS/PSP

YAP/TAZ Signaling Pathway in Neurodegeneration

Neuroregeneration Therapies for Neurodegeneration

stem-cell-therapy

SOX2

Section 127: Advanced Cell Therapy and Transplantation in CBS/PSP

Induced Pluripotent Stem Cell (iPSC) Disease Models

Section 248: Epigenetic Clock Reversal Deep Dive in CBS/PSP

ASCL1 Gene

SOX2 Protein

iPSC Cell Therapy for Parkinson's Disease

Brain Organoids

Cerebral Vascular Smooth Muscle Cells

NYSCF Scientific Discovery Biobank (NCT06203106)

OSK Reprogramming and Yamanaka Factors in Neurodegeneration

POU5F1 (Oct4) - POU Class 5 Homeobox 1