gene

KLF4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KLF4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

246Connections

3Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

KLF4 (Kruppel-Like Factor 4) is a zinc-finger transcription factor essential for cellular reprogramming, neuroprotection, and neural stem cell maintenance, with implications for Alzheimer's and Parkinson's disease therapy.

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🧬 Gene Info

Gene Symbol	KLF4
Full Name	Kruppel-Like Factor 4
Chromosome	9q31.2
Protein Type	Transcription Factor
Function	Cell cycle control: Represses proliferation genes (c-Myc, cyclin D1) while activating cell cycle inhibitors (p21, p27)
Primary Expression	High in brain, GI tract, endothelial cells
Amino Acids	483 aa
Pathways	Akt, Amyloid, Epigenetic, Neurogenesis, Nf-Kb
UniProt ID	O43474
NCBI Gene ID	9312
Ensembl ID	ENSG00000109576
OMIM	602253
GeneCards	KLF4
Human Protein Atlas	KLF4
Associated Diseases	aging, Atherosclerosis, Inflammation, Ms, neurodegeneration, Senescence
Interactions	AND, APOPTOSIS, App, ARG1, ATG7, ATP2A3
SciDEX Hypotheses	KLF4-Mediated Transcriptional Repression of P2RY12 Temporal Chromatin Oscillator Reset Therapy
KG Connections	246 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KLF4 — AlphaFold O43474 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KLF4 Gene

gene · 1210 words

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Pathway Diagram

flowchart TD
    KLF4["KLF4"] -->|"regulates"| Ms["Ms"]
    KLF4["KLF4"] -->|"regulates"| Inflammation["Inflammation"]
    KLF4["KLF4"] -->|"activates"| Cancer["Cancer"]
    KLF4["KLF4"] -->|"activates"| Tumor["Tumor"]
    KLF4["KLF4"] -->|"associated with"| Stroke["Stroke"]
    KLF4["KLF4"] -->|"associated with"| Ms["Ms"]
    KLF4["KLF4"] -->|"associated with"| Atherosclerosis["Atherosclerosis"]
    KLF4["KLF4"] -->|"expressed in"| Aging["Aging"]
    KLF4["KLF4"] -.->|"inhibits"| Ms["Ms"]
    KLF4["KLF4"] -->|"biomarker for"| Aging["Aging"]
    KLF4["KLF4"] -->|"activates"| Senescence["Senescence"]
    KLF4["KLF4"] -->|"activates"| Cardiovascular["Cardiovascular"]
    style KLF4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
    style Atherosclerosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Senescence fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (161)

Target	Relation	Type	Str
iPSC Reprogramming	involved_in	process	0.95
ATP2A3	binds	gene	0.95
BIG1	regulates	gene	0.95
ATP2A3	activates	gene	0.95
Pluripotency	associated_with	process	0.90
Embryonic Stem Cells	expressed_in	cell_type	0.90
VSMC phenotypic switching	regulates	process	0.90
Pluripotency	activates	phenotype	0.90
Cellular Senescence	associated_with	process	0.85
Transcription	regulates	process	0.85
Neuro-inflammation	mediates	process	0.80
Resilience	downregulates	phenotype	0.75
Aging	expressed_in	disease	0.75
Tumor	activates	disease	0.75
SOX2	regulates	gene	0.70
Aging	regulates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	regulates	disease	0.65
Dementia	regulates	disease	0.65
ALS	regulates	disease	0.65
Ms	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Senescence	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	biomarker_for	disease	0.65
Ms	inhibits	disease	0.65
Senescence	activates	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Cancer	activates	disease	0.65
Stroke	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Inflammation	activates	disease	0.65
P62	regulates	gene	0.60
BNIP3	regulates	gene	0.60
OCT4	biomarker_for	gene	0.60
MAP1LC3B	activates	gene	0.60
P62	activates	gene	0.60
DNMT3A	activates	gene	0.60
JUND	inhibits	gene	0.60
MTOR	therapeutic_target	gene	0.60
MYC	regulates	gene	0.60
OCT4	activates	gene	0.60
AKT	therapeutic_target	gene	0.60

Incoming (85)

Source	Relation	Type	Str
SOX2	interacts_with	gene	0.90
PI3K	therapeutic_target	gene	0.70
AGING	expressed_in	gene	0.70
OCT4	regulates	gene	0.70
GAIN	regulates	gene	0.60
AKT	regulates	gene	0.60
PI3K	regulates	gene	0.60
OCT4	activates	gene	0.60
OCT4	biomarker_for	gene	0.60
MYC	biomarker_for	gene	0.60
SOX2	biomarker_for	gene	0.60
DNMT3A	activates	gene	0.60
SOX2	regulates	gene	0.60
GFAP	activates	gene	0.60
TAU	regulates	gene	0.60
MIRNAS	associated_with	gene	0.60
AGING	biomarker_for	gene	0.60
RNA	regulates	gene	0.60
TNF	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
ATG7	activates	gene	0.60
PPARG	activates	gene	0.60
CLOCK	associated_with	gene	0.60
PPAR	therapeutic_target	gene	0.60
PARKIN	regulates	gene	0.60
PINK1	regulates	gene	0.60
LC3	regulates	gene	0.60
EXOSOMES	therapeutic_target	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
IL-6	regulates	gene	0.60
TNF-Α	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
IL-10	regulates	gene	0.60
AND	regulates	gene	0.60
FOXO3	activates	gene	0.60
FOS	associated_with	gene	0.60
MYC	expressed_in	gene	0.60
SOX2	expressed_in	gene	0.60
FOS	inhibits	gene	0.60
RELA	inhibits	gene	0.60
MYC	inhibits	gene	0.60
AKT	therapeutic_target	gene	0.60
NOS2	activates	gene	0.60
ARG1	activates	gene	0.60
DEPTOR	regulates	gene	0.60
ERK	activates	gene	0.60
HIF1	activates	gene	0.60
GENES	regulates	gene	0.60
POU5F1	activates	gene	0.60
DUSP9	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Transient OCT4/SOX2/KLF4/c-MYC Expression Reverses Epigeneti	0.540	neurodegeneration	epigenetic reprogramming aging neurons
KLF4-Mediated Transcriptional Repression of P2RY12	0.440	neurodegeneration	What determines P2RY12 receptor expressi
Temporal Chromatin Oscillator Reset Therapy	0.000	-	Epigenetic reprogramming in aging neuron

Mentioning Analyses (2)

Scientific analyses that reference this entity

What determines P2RY12 receptor expression/activity specifically in VSMCs during

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.650

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 16 hypotheses Top: 0.779

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning KLF4 in their description or question text

No additional research found

KLF4

Understanding Entity Pages

Summary

Wiki Pages (1)

KLF4 Gene

Pathway Diagram

Outgoing (161)

Incoming (85)

Targeting Hypotheses (3)

Mentioning Analyses (2)

What determines P2RY12 receptor expression/activity specifically in VSMCs during

Epigenetic reprogramming in aging neurons

Experiments (0)

Related Papers (0)

Debates (4)

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation

The study shows P2RY12 regulates VSMC foam cell formation but doesn't explain wh

Epigenetic reprogramming in aging neurons

Related Research