Retromer Complex

Understanding Entity Pages

This page aggregates everything SciDEX knows about Retromer Complex: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

The retromer complex is a highly conserved multi-protein assembly that mediates the retrograde transport of transmembrane proteins from endosomes back to the trans-Golgi network (TGN) or the plasma membrane. In the central nervous system, retromer dysfunction has emerged as a convergent pathogenic m

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flowchart TD
    Retromer_Complex{{"Retromer Complex"}}
    Protein_Trafficking("Protein Trafficking")
    Retromer_Complex -->|"involved in"| Protein_Trafficking
    Endolysosomal_System("Endolysosomal System")
    Retromer_Complex -->|"regulates"| Endolysosomal_System
    Receptor_Recycling("Receptor Recycling")
    Retromer_Complex -->|"mediates"| Receptor_Recycling
    VPS35(["VPS35"])
    VPS35 -->|"component of"| Retromer_Complex
    RAB7A(["RAB7A"])
    RAB7A -->|"interacts with"| Retromer_Complex
    Tau_Pathobiology("Tau Pathobiology")
    Retromer_Complex -->|"involved in"| Tau_Pathobiology

    style Retromer_Complex fill:#4a148c,stroke:#4fc3f7,stroke-width:3px,color:#fff