gene

VPS29

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS29: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections
0Hypotheses
0Analyses
25Outgoing
18Incoming

Summary

VPS29 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Alzheimer, Tauopathy. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolVPS29
Chromosome12q24.33
Functionis a critical component of the retromer complex, a highly conserved protein assembly that plays a fundamental role in endosomal trafficking throughout the cell.
Molecular Weight21 kDa
Amino Acids182 aa
Exons5
PathwaysCRISPR-Cas, Stem Cell
UniProt IDQ9BRT6
NCBI Gene ID51699
Ensembl IDENSG00000136840
GeneCardsVPS29
Human Protein AtlasVPS29
SubunitMolecular Weight
VPS3592 kDa
VPS26A/B38 kDa
Associated Diseasesneurodegeneration
InteractionsMAPT, TAU, VPS35, GENES, ALZHEIMER'S DISEASE, TAUOPATHY
KG Connections43 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: VPS29 — AlphaFold Q9BRT6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

VPS29 Gene

gene · 1467 words

cbs-psp-daily-action-plan

therapeutic · 30834 words

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

mechanism · 3583 words

Retromer Dysfunction in Corticobasal Syndrome

mechanism · 3576 words

SNX3 Protein — Sorting Nexin 3 in Neurodegeneration

protein · 3294 words

Endosomal Sorting Defects in Neurodegeneration

mechanism · 3248 words

Pathway Diagram

graph TD
    VPS29["VPS29"]
    Tauopathy{"Tauopathy"}
    VPS29 -->|"activates"| Tauopathy
    Als{"Als"}
    VPS29 -->|"activates"| Als
    Alzheimer{"Alzheimer"}
    VPS29 -->|"activates"| Alzheimer
    GENES["GENES"]
    VPS29 -->|"activates"| GENES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    VPS29 -->|"activates"| ALZHEIMER_S_DISEASE
    TAUOPATHY["TAUOPATHY"]
    VPS29 -->|"activates"| TAUOPATHY
    MAPT["MAPT"]
    VPS29 -->|"activates"| MAPT
    Stem_Cell(["Stem Cell"])
    VPS29 -->|"activates"| Stem_Cell
    TAU["TAU"]
    TAU -->|"activates"| VPS29
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| VPS29
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| VPS29
    PSP["PSP"]
    PSP -->|"activates"| VPS29
    GENES -->|"activates"| VPS29
    MAPT -->|"activates"| VPS29
    ALZHEIMER_S_DISEASE -->|"activates"| VPS29

Outgoing (25)

TargetRelationTypeStr
RETROMER COMPLEXcomponent_ofprotein0.95
Tau Propagationmodulatesprocess0.85
Tauopathyactivatesdisease0.65
Alsactivatesdisease0.65
Alzheimeractivatesdisease0.65

Incoming (18)

SourceRelationTypeStr
TAUactivatesgene0.60
PSPactivatesgene0.60
MAPTactivatesgene0.60
BECN1targetsgene0.60
CYP27B1targetsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found