Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VPS29: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
VPS29 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Alzheimer, Tauopathy. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | VPS29 |
| Chromosome | 12q24.33 |
| Function | is a critical component of the retromer complex, a highly conserved protein assembly that plays a fundamental role in endosomal trafficking throughout the cell. |
| Molecular Weight | 21 kDa |
| Amino Acids | 182 aa |
| Exons | 5 |
| Pathways | CRISPR-Cas, Stem Cell |
| UniProt ID | Q9BRT6 |
| NCBI Gene ID | 51699 |
| Ensembl ID | ENSG00000136840 |
| GeneCards | VPS29 |
| Human Protein Atlas | VPS29 |
| Subunit | Molecular Weight |
| VPS35 | 92 kDa |
| VPS26A/B | 38 kDa |
| Associated Diseases | neurodegeneration |
| Interactions | MAPT, TAU, VPS35, GENES, ALZHEIMER'S DISEASE, TAUOPATHY |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
VPS29["VPS29"]
Tauopathy{"Tauopathy"}
VPS29 -->|"activates"| Tauopathy
Als{"Als"}
VPS29 -->|"activates"| Als
Alzheimer{"Alzheimer"}
VPS29 -->|"activates"| Alzheimer
GENES["GENES"]
VPS29 -->|"activates"| GENES
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
VPS29 -->|"activates"| ALZHEIMER_S_DISEASE
TAUOPATHY["TAUOPATHY"]
VPS29 -->|"activates"| TAUOPATHY
MAPT["MAPT"]
VPS29 -->|"activates"| MAPT
Stem_Cell(["Stem Cell"])
VPS29 -->|"activates"| Stem_Cell
TAU["TAU"]
TAU -->|"activates"| VPS29
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"activates"| VPS29
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
NEURODEGENERATIVE_DISEASES -->|"activates"| VPS29
PSP["PSP"]
PSP -->|"activates"| VPS29
GENES -->|"activates"| VPS29
MAPT -->|"activates"| VPS29
ALZHEIMER_S_DISEASE -->|"activates"| VPS29| Target | Relation | Type | Str |
|---|---|---|---|
| RETROMER COMPLEX | component_of | protein | 0.95 |
| Tau Propagation | modulates | process | 0.85 |
| Tauopathy | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| MAPT | activates | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| VPS35 | targets | gene | 0.60 |
| YBX1 | targets | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| TAUOPATHY | activates | gene | 0.60 |
| Stem Cell | activates | pathway | 0.60 |
| GENETIC MODIFIERS | activates | gene | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| App | activates | protein | 0.60 |
| CRISPR-Cas | participates_in | pathway | 0.60 |
| VPS35 | binds_to | gene | 0.55 |
| VPS35 | interacts_with | gene | 0.55 |
| Stem Cell | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| RETROMER | activates | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TAU | activates | gene | 0.60 |
| PSP | activates | gene | 0.60 |
| MAPT | activates | gene | 0.60 |
| BECN1 | targets | gene | 0.60 |
| CYP27B1 | targets | gene | 0.60 |
| GCLC | targets | gene | 0.60 |
| PCBP2 | targets | gene | 0.60 |
| PEX13 | targets | gene | 0.60 |
| PPP1CA | targets | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| GENETIC MODIFIERS | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| TAUOPATHY | activates | gene | 0.60 |
| VPS26 | binds_to | gene | 0.55 |
| VPS26 | interacts_with | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||