gene

VPS35

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS35: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

381Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Gene profile: VPS35 — retromer complex component linked to PARK17 Parkinson's disease

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🧬 Gene Info

Gene Symbol	VPS35
Full Name	Vacuolar Protein Sorting 35 Homolog
Aliases	Vacuolar Protein Sorting 35
Protein Type	Protein
Function	Cargo Recognition: Binds to transmembrane cargo proteins containing cytoplasmic sorting motifs
Molecular Weight	91.6 kDa
Amino Acids	796 aa
Pathways	Wnt
UniProt ID	Search UniProt
GeneCards	VPS35
Human Protein Atlas	VPS35
Associated Diseases	ALS, Alzheimer, Alzheimer's Disease, Amyotrophic Lateral Sclerosis
Interactions	EIF4G1, GAIN, LRRK2, MITOCHONDRIA, PYROPTOSIS, LYSOSOME
KG Connections	381 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: VPS35 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VPS35["VPS35"]
    VPS35 -->|"causes"| PD["PD"]
    VPS35 -->|"contributes to"| Parkinson["Parkinson"]
    VPS35 -->|"contributes to"| Als["Als"]
    VPS35 -->|"contributes to"| Inflammation["Inflammation"]
    VPS35 -->|"contributes to"| Neuroinflammation["Neuroinflammation"]
    VPS35 -->|"contributes to"| Ms["Ms"]
    VPS35 -->|"target for"| Aging["Aging"]
    PARK7["PARK7"] -->|"contributes to"| VPS35
    PINK1["PINK1"] -->|"contributes to"| VPS35
    GBA1["GBA1"] -->|"contributes to"| VPS35
    SNCA["SNCA"] -->|"contributes to"| VPS35
    LRRK2["LRRK2"] -->|"contributes to"| VPS35
    PRKN["PRKN"] -->|"contributes to"| VPS35
    AGING["AGING"] -->|"target for"| VPS35
    FLAVONOIDS["FLAVONOIDS"] -->|"target for"| VPS35
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"target for"| VPS35
    DRP1["DRP1"] -->|"interacts"| VPS35

Outgoing (204)

Target	Relation	Type	Str
p.D620N mutation	causes	mechanism	0.95
Retinal Degeneration	contributes_to	phenotype	0.95
Late Endosomal Trafficking	regulates	process	0.95
Retromer-Dependent Endosomal Trafficking	involved_in	process	0.95
TAU	regulates	protein	0.95
Parkinson's Disease	causes	disease	0.95
Parkinson's Disease	contributes_to	disease	0.95
Parkinson's disease	risk_factor_for	disease	0.95
Retromer Complex	component_of	pathway	0.95
PINK1/parkin-mediated mitophagy	inhibits	pathway	0.90
Presynaptic Trafficking	regulates	process	0.90
Endo-Lysosome System	regulates	organelle	0.90
TRPL	regulates	protein	0.90
APLP1	regulates	protein	0.90
CHL1	regulates	protein	0.90
Α-SYNUCLEIN	associated_with	protein	0.90
HSC70	interacts_with	protein	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.90
Alzheimer's Disease	associated_with	disease	0.90
MAPL-Induced Pyroptosis	regulates	process	0.85
Inflammatory Cell Death	regulates	process	0.85
LRRK2	modulates	protein	0.85
LRRK2 kinase activity	upregulates	mechanism	0.85
GLUA1	regulates	receptor	0.85
Amyloid Precursor Protein Cleavage	regulates	process	0.85
SYNAPTIC GLUTAMATE RECEPTORS	regulates	receptor	0.85
Phosphorylated Tau	downregulates	entity	0.85
Protein Transport	mediates	process	0.85
TAU PROTEIN	regulates	protein	0.85
DAT	interacts_with	protein	0.85
Mapl-Induced Pyroptosis	regulates	process	0.80
Microglial Phenotype	regulates	phenotype	0.80
Ubiquitin-Proteasome System	regulates	process	0.80
autophagy pathway	participates_in	pathway	0.80
Parkinson's disease	implicated_in	disease	0.80
Parkinson	contributes_to	disease	0.75
Parkinson'S Disease	associated_with	disease	0.75
PD	causes	disease	0.72
BST-2	regulates	protein	0.70
Parkinson's Disease	implicated_in	disease	0.70
Als	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Ms	contributes_to	disease	0.65
Parkinson	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	regulates	disease	0.65

Incoming (177)

Source	Relation	Type	Str
SYNJ1	interacts_with	gene	0.95
FAF2	interacts_with	entity	0.85
PARKINSON'S DISEASE	contributes_to	gene	0.70
PARKINSON	contributes_to	gene	0.70
LRRK2	regulates	gene	0.65
PARKINSON	associated_with	gene	0.65
NEURON	degrades	cell_type	0.65
PARK7	contributes_to	gene	0.60
PINK1	contributes_to	gene	0.60
GBA1	contributes_to	gene	0.60
SNCA	contributes_to	gene	0.60
LRRK2	contributes_to	gene	0.60
PRKN	contributes_to	gene	0.60
LRRK2	co_discussed	gene	0.60
PARK7	co_discussed	gene	0.60
PINK1	co_discussed	gene	0.60
PRKN	co_discussed	gene	0.60
SNCA	co_discussed	gene	0.60
LRRK2	associated_with	gene	0.60
SYNJ1	associated_with	gene	0.60
DNAJC6	associated_with	gene	0.60
DRP1	interacts_with	gene	0.60
MFN2	regulates	gene	0.60
DNM1L	regulates	gene	0.60
ATXN2	activates	gene	0.60
LRRK2	activates	gene	0.60
ATP13A2	activates	gene	0.60
PINK1	causes	gene	0.60
LRRK2	causes	gene	0.60
PARKIN	associated_with	gene	0.60
DJ1	associated_with	gene	0.60
ATG5	regulates	gene	0.60
PINK1	associated_with	entity	0.60
STAT3	activates	gene	0.60
SRC	activates	gene	0.60
UBIQUITIN	regulates	gene	0.60
GCH1	associated_with	gene	0.60
CGAS	regulates	gene	0.60
GBA1	causes	gene	0.60
PARK7	causes	gene	0.60
PRKN	causes	gene	0.60
PRKN	associated_with	gene	0.60
DJ1	causes	gene	0.60
SNCA	expressed_in	gene	0.60
LRRK2	expressed_in	gene	0.60
RAB10	expressed_in	gene	0.60
PICALM	activates	gene	0.60
SIRT3	activates	gene	0.60
SNCA	inhibits	gene	0.60
UCHL1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

VPS35

Understanding Entity Pages

Summary

Wiki Pages (21)

VPS35 — Vacuolar Protein Sorting 35 Homolog

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Parkinson's Disease

Vascular Cognitive Impairment (VCI)

Synaptic Vesicle Trafficking in Parkinson's Disease

GBA Pathway in Parkinson's Disease

proteasome-ubiquitin-system-dysfunction-parkinsons

ZFYVE26 Gene

sporadic-familial-pd-comparison

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

Lysosomal Dysfunction in Neurodegeneration

Retromer Dysfunction in Corticobasal Syndrome

Alpha-Synuclein ESCRT-III Inhibition Mechanism

ubiquitin-proteasome-dysfunction-neurodegeneration

DNAJC13 — DnaJ Heat Shock Protein Family Member C13

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

SNX3 Protein — Sorting Nexin 3 in Neurodegeneration