Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SEPTIN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SEPTIN2 |
| Aliases | SEPT2, SEPTIN2, DIFF6, NEDD5 |
| Chromosome | 2q37.3 |
| Protein Family | Septin GTPases |
| Function | is a founding member of the septin family of GTP-binding proteins that play essential roles in cytoskeletal organization, membrane dynamics, and cellular signaling. |
| Molecular Weight | 41.5 kDa |
| Amino Acids | 361 aa |
| UniProt ID | Q15020 |
| NCBI Gene ID | 4735 |
| OMIM | 601680 |
| GeneCards | SEPTIN2 |
| Human Protein Atlas | SEPTIN2 |
| Gene Name | Septin 2 |
| Associated Diseases | neurodegeneration |
| Interactions | RAC1, INFLAMMATION |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SEPTIN2["<b>SEPTIN2</b>"]
Cardiovascular{"Cardiovascular"}
SEPTIN2 -->|"activates"| Cardiovascular
Inflammation{"Inflammation"}
SEPTIN2 -->|"activates"| Inflammation
RAC1["RAC1"]
SEPTIN2 -->|"activates"| RAC1
INFLAMMATION["INFLAMMATION"]
SEPTIN2 -->|"activates"| INFLAMMATION
neurodegeneration["neurodegeneration"]
SEPTIN2 -->|"implicated in"| neurodegeneration
style SEPTIN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cardiovascular | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| RAC1 | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||