Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SHP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Src Homology 2 Domain-Containing Phosphatase 2 - a protein tyrosine phosphatase that regulates RAS-RAF-MEK-ERK signaling and is implicated in neurodegeneration
| Gene Symbol | SHP2 |
| Aliases | Src Homology 2 Domain-Containing Phosphatase 2 |
| Chromosome | 12q24.13 |
| Function | The PTPN11 gene (located on chromosome 12q24.13 in humans) encodes a protein of 593 amino acids with a molecular weight of approximately 68 kDa. |
| Subcellular Localization | are tightly regulated, with dysregulation contributing to neuronal dysfunction a |
| Molecular Weight | 68 kDa |
| Amino Acids | 593 aa |
| GeneCards | SHP2 |
| Human Protein Atlas | SHP2 |
| Interactions | IL-10, PKA |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SHP2(["SHP2"])
cancer["cancer"]
CELL_PROLIFERATION["CELL PROLIFERATION"]
IL_10(["IL-10"])
PKA(["PKA"])
SHP2 -->|"activates"| cancer
SHP2 -->|"activates"| CELL_PROLIFERATION
IL_10 -->|"activates"| SHP2
PKA -->|"activates"| SHP2
style SHP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style cancer fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
style CELL_PROLIFERATION fill:#1a1a2e,stroke:#ffd54f,stroke-width:2px,color:#fff
style IL_10 fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
style PKA fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| cancer | activates | disease | 0.50 |
| CELL PROLIFERATION | activates | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||