protein

IL-10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

740Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Interleukin-10 (IL-10) — an anti-inflammatory cytokine that modulates neuroinflammation in Alzheimer's and Parkinson's disease through JAK-STAT3 signaling.

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🔬 Protein Info

Gene Symbol	IL
Function	Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation.
GeneCards	IL
Human Protein Atlas	IL
Associated Diseases	CRC
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IL10["IL-10"]
    S1P1["S1P1 Receptor"]
    TNF["TNF-alpha"]
    IL6["IL-6"]
    AKT["AKT"]
    NRF2["Nrf2"]
    MICROGLIA["Microglia"]
    NEUROINFLAM["Neuroinflammation"]
    INFLAM["Inflammation"]
    SPHINGO["Sphingolipid Metabolism"]
    APOPTOSIS["Apoptosis"]
    ALZHEIMER["Alzheimer's Disease"]
    PARKINSON["Parkinson's Disease"]
    AMYLOID["Amyloid Beta"]
    LRRK2["LRRK2"]
    PARKIN["Parkin"]

    S1P1 -->|"upregulates"| IL10
    AKT -->|"promotes"| IL10
    NRF2 -->|"enhances"| IL10
    MICROGLIA -->|"produces"| IL10
    
    TNF -->|"inhibits"| IL10
    IL6 -->|"inhibits"| IL10
    AMYLOID -->|"suppresses"| IL10
    
    IL10 -->|"inhibits"| NEUROINFLAM
    IL10 -->|"suppresses"| INFLAM
    IL10 -->|"regulates"| SPHINGO
    IL10 -->|"protects against"| APOPTOSIS
    
    NEUROINFLAM -->|"contributes to"| ALZHEIMER
    NEUROINFLAM -->|"contributes to"| PARKINSON
    LRRK2 -->|"associated with"| PARKINSON
    PARKIN -->|"associated with"| PARKINSON
    
    style IL10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style S1P1 fill:#1b5e20,stroke:#333,stroke-width:2px
    style AKT fill:#4a1a6b,stroke:#333,stroke-width:2px
    style NRF2 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style TNF fill:#ef5350,stroke:#333,stroke-width:2px
    style IL6 fill:#ef5350,stroke:#333,stroke-width:2px
    style NEUROINFLAM fill:#ef5350,stroke:#333,stroke-width:2px
    style INFLAM fill:#ef5350,stroke:#333,stroke-width:2px
    style ALZHEIMER fill:#7d4200,stroke:#333,stroke-width:2px
    style PARKINSON fill:#7d4200,stroke:#333,stroke-width:2px
    style MICROGLIA fill:#1b5e20,stroke:#333,stroke-width:2px

Outgoing (480)

Target	Relation	Type	Str
Sphingolipid Metabolism	inhibits	pathway	0.95
Inflammation	inhibits	process	0.95
Sphingolipids	regulates	compound	0.90
Sphingolipid Metabolism	modulates	pathway	0.90
TGF	activates	gene	0.85
unfolded protein response	participates_in	pathway	0.85
TGF-beta signaling	participates_in	pathway	0.85
neurotrophin signaling	participates_in	pathway	0.85
microglia	expressed_in	cell_type	0.85
Neuroinflammation	inhibits	process	0.80
sphingolipid metabolism	associated_with	biological_process	0.80
inflammation	associated_with	disease	0.80
Psoriasis	associated_with	disease	0.80
MACROPHAGES	activates	cell_type	0.80
NF-kB signaling	participates_in	pathway	0.75
astrocytes	expressed_in	cell_type	0.75
Neuroinflammation	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Alzheimer	activates	disease	0.65
Inflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Multiple Sclerosis	biomarker_for	disease	0.65
Huntington	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Parkinson	biomarker_for	disease	0.65
Ischemia	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Tumor	activates	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Pain	regulates	disease	0.65
Tumor	causes	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Anxiety	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	regulates	disease	0.65
Ms	regulates	disease	0.65
Alzheimer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Ms	causes	disease	0.65
Inflammation	causes	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65

Incoming (260)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	0.98
TNF	inhibits	gene	0.90
LRWE	upregulates	compound	0.90
S1P1	upregulates	receptor	0.85
IL-6	inhibits	gene	0.82
AMYLOID	associated_with	protein	0.82
PARKINSON'S DISEASE	associated_with	disease	0.82
IL-6	associated_with	gene	0.82
MICROGLIA	associated_with	cell_type	0.82
DHT	upregulates	compound	0.80
DHT	modulates	compound	0.75
GDNF	activates	gene	0.75
CD68	activates	gene	0.75
MICROGLIA	inhibits	cell_type	0.74
IL-6	activates	gene	0.66
TNF	activates	gene	0.66
TNF	associated_with	gene	0.66
CD38	promotes	gene	0.65
ATP	interacts_with	gene	0.65
BDNF	causes	gene	0.65
ASTROCYTE	promotes	cell_type	0.65
ASTROCYTES	promotes	cell_type	0.65
GFAP	promotes	gene	0.65
CX3CR1	regulates	gene	0.65
HDAC	activates	gene	0.65
CREB	activates	gene	0.65
AKT	associated_with	gene	0.64
BAX	associated_with	gene	0.64
NF-KB	associated_with	protein	0.64
P38	activates	gene	0.60
PARKINSON	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
SYNAPTOPHYSIN	activates	gene	0.60
TNF-Α	activates	gene	0.60
MICROGLIA	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
BAX	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NF-ΚB	activates	gene	0.60
AND	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	biomarker_for	gene	0.60
PARKINSON	biomarker_for	gene	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
AND	activates	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	associated_with	gene	0.60
TNFR1	activates	gene	0.60
TNF	causes	gene	0.60
IL-4	regulates	gene	0.60
AND	causes	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral	0.601	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL-10

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Device Therapies Comparison for CBS/PSP

neuroinflammation

NTF4 Protein

TREM2 Mechanism Hub

Astrocyte Reactivity Mechanism

TREM2 Microglial Signaling Pathway in Neurodegeneration

vitamin-d-therapy-neurodegeneration

Histamine

FGF10 — Fibroblast Growth Factor 10

NF-kB Signaling Pathway in Neurodegeneration

Psychobiotic Therapy for Neurodegenerative Diseases

Neuroinflammation Across AD, PD, ALS, FTD, and HD

TREM2→Microglial Dysfunction→Alzheimer's Disease Causal Chain

cynata-therapeutics

cGMP Signaling Pathway in Neurodegeneration

Endocannabinoid System Dysfunction Hypothesis in Parkinson's Disease

TGF-β Signaling in Parkinson's Disease