Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CELL PROLIFERATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CELL PROLIFERATION |
| Key Genes/Proteins | MTOR, AKT, PI3K, CYP46A1 |
| Related Diseases | CANCER, APOPTOSIS, CHEMORESISTANCE, CELL DEATH |
Knowledge base pages for this entity
graph TD
CELL_PROLIFERATION["CELL PROLIFERATION"]
style CELL_PROLIFERATION fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
Luteolin["Luteolin"] -.->|"inhibits"| CELL_PROLIFERATION
MTOR([MTOR]) -->|"regulates"| CELL_PROLIFERATION
PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"regulates"| CELL_PROLIFERATION
Shikonin["Shikonin"] -.->|"inhibits"| CELL_PROLIFERATION
HER2([HER2]) -->|"regulates"| CELL_PROLIFERATION
FGFR["FGFR"] -->|"regulates"| CELL_PROLIFERATION
PI3K_AKT_MTOR["PI3K/AKT/MTOR"] -->|"regulates"| CELL_PROLIFERATION| Target | Relation | Type | Str |
|---|---|---|---|
| MTOR | activates | gene | 0.80 |
| METASTASIS | activates | process | 0.80 |
| PI3K | activates | gene | 0.65 |
| APOPTOSIS | treats | phenotype | 0.65 |
| CHEMORESISTANCE | inhibits | phenotype | 0.65 |
| CELL DEATH | inhibits | phenotype | 0.65 |
| EGFR | activates | gene | 0.50 |
| INFLAMMATION | activates | process | 0.50 |
| ENDOTHELIAL CELLS | activates | cell_type | 0.50 |
| NEURON | regulates | cell_type | 0.50 |
| NEURON | activates | cell_type | 0.50 |
| INFLAMMATION | implicated_in | process | 0.50 |
| HEPATOCELLULAR CARCINOMA | activates | disease | 0.50 |
| NF-KB | regulates | gene | 0.50 |
| MTOR SIGNALING | activates | process | 0.50 |
| RAPAMYCIN | regulates | drug | 0.50 |
| HER2 | activates | concept | 0.50 |
| RAPAMYCIN | associated_with | concept | 0.50 |
| CENTRAL NERVOUS SYSTEM | activates | concept | 0.50 |
| EXTRACELLULAR MATRIX | associated_with | concept | 0.50 |
| HER2 | associated_with | concept | 0.50 |
| PI3K/AKT PATHWAY | activates | concept | 0.50 |
| IL-17 | associated_with | concept | 0.50 |
| SGMS1 | associated_with | concept | 0.50 |
| SGMS1 | regulates | concept | 0.50 |
| SRPK1 | expressed_in | concept | 0.50 |
| SRPK1 | regulates | concept | 0.50 |
| CELL MIGRATION | associated_with | concept | 0.50 |
| FERROPTOSIS | activates | process | 0.50 |
| SLC7A11 | activates | gene | 0.50 |
| MICROGLIA | activates | cell_type | 0.45 |
| IL6 | activates | gene | 0.45 |
| CURCUMIN | associated_with | drug | 0.45 |
| PI3K/AKT/MTOR | associated_with | pathway | 0.45 |
| MTOR PATHWAY | associated_with | pathway | 0.45 |
| RIBOSOME | associated_with | organelle | 0.45 |
| BAICALEIN | associated_with | drug | 0.45 |
| PI3K/AKT PATHWAY | associated_with | pathway | 0.45 |
| MTOR SIGNALING | associated_with | pathway | 0.45 |
| LUTEOLIN | associated_with | drug | 0.45 |
| WNT SIGNALING | associated_with | pathway | 0.45 |
| FGF2 | co_discussed | gene | 0.40 |
| MTOR | co_discussed | gene | 0.40 |
| PI3K | co_discussed | gene | 0.40 |
| SENESCENCE | co_discussed | process | 0.40 |
| FERROPTOSIS | co_discussed | process | 0.40 |
| METASTASIS | co_discussed | process | 0.40 |
| NECROPTOSIS | co_discussed | process | 0.40 |
| LUNG CANCER | co_discussed | disease | 0.40 |
| EGFR | co_discussed | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MTOR | regulates | entity | 0.95 |
| CANCER | activates | disease | 0.95 |
| APOPTOSIS | activates | process | 0.95 |
| APOPTOSIS | regulates | process | 0.95 |
| PRMT1 | regulates | entity | 0.90 |
| AKT | activates | gene | 0.80 |
| APOPTOSIS | associated_with | process | 0.80 |
| CANCER | associated_with | disease | 0.65 |
| CYP46A1 | inhibits | gene | 0.65 |
| GLYCOLYSIS | causes | phenotype | 0.65 |
| AUTOPHAGY | treats | phenotype | 0.65 |
| CANCER | interacts_with | disease | 0.65 |
| LUTEOLIN | activates | drug | 0.65 |
| CELL MIGRATION | regulates | phenotype | 0.65 |
| CLU | stabilizes | gene | 0.65 |
| CANCER | implicated_in | disease | 0.55 |
| FGF2 | implicated_in | gene | 0.55 |
| CLU | expressed_in | gene | 0.55 |
| CLU | implicated_in | gene | 0.55 |
| BREAST CANCER | inhibits | disease | 0.50 |
| APOPTOSIS | implicated_in | process | 0.50 |
| CANCER | inhibits | disease | 0.50 |
| cancer | expressed_in | disease | 0.50 |
| TUMOR | expressed_in | disease | 0.50 |
| PRMT1 | expressed_in | concept | 0.50 |
| Pancreatic Cancer | expressed_in | disease | 0.50 |
| TET2 | activates | gene | 0.50 |
| T Cell | activates | cell_type | 0.50 |
| Pi3K | activates | pathway | 0.50 |
| PTEN | activates | gene | 0.50 |
| mTOR | activates | entity | 0.50 |
| cancer | activates | disease | 0.50 |
| TUMOR | activates | disease | 0.50 |
| GLYCOLYSIS | activates | pathway | 0.50 |
| Pi3K/Akt | activates | pathway | 0.50 |
| PI3K/AKT/mTOR | activates | pathway | 0.50 |
| MITOCHONDRIA | activates | cell_type | 0.50 |
| PFKL | activates | protein | 0.50 |
| apoptosis | activates | process | 0.50 |
| Invasion | activates | pathway | 0.50 |
| Pancreatic Cancer | activates | disease | 0.50 |
| Cellular Senescence | interacts_with | cell_type | 0.50 |
| EGFR | activates | gene | 0.50 |
| FGF2 | associated_with | gene | 0.50 |
| Stem Cell | associated_with | cell_type | 0.50 |
| ACVR2A | activates | gene | 0.50 |
| STAT3 | activates | gene | 0.50 |
| inflammation | activates | pathway | 0.50 |
| OBESITY | activates | disease | 0.50 |
| Jak-Stat | activates | pathway | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||