gene 1,383 words KG: TRKB 2026-03-24
kind:genesection:genesstate:published
Contents

TRKB Gene

🧬 Gene Info
Gene SymbolTRKB
Chromosome9q21.33
Protein TypeReceptor
Functionis a high-affinity receptor tyrosine kinase that serves as the primary signaling receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4).
Molecular Weight140 kDa
Amino Acids796 aa
Exons24
PathwaysAkt, Apoptosis, Cell Cycle, Long-Term Potentiation, Mapk
UniProt IDQ16620
NCBI Gene ID4915
Ensembl IDENSG00000148053
GeneCardsTRKB
Human Protein AtlasTRKB
7,8-DHFSmall molecule
R13Peptide mimetic
Associated DiseasesALS, Aging, Alzheimer, Alzheimer'S Disease, Cancer
InteractionsMMP2, SYN3, MMP9, BDNF, PI3K, MTOR
KG Connections973 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (23)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (13)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (1)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (3)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: inhibits

Knowledge Graph (12 edges)

TRKB activates MMP2
TRKB activates SYN3
TRKB activates MMP9
TRKB activates BDNF
TRKB associated_with BDNF
TRKB therapeutic_target RB1
TRKB regulates PI3K
TRKB regulates BDNF
TRKB regulates NRF2
TRKB regulates AKT