concept

SIRTUINS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIRTUINS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

1Analyses

15Outgoing

2Incoming

0Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	SIRTUINS
Key Genes/Proteins	HISTONE_DEACETYLASE
Related Diseases	APOPTOSIS, Cardiovascular Disease, CARDIOVASCULAR_DISEASE, CELLULAR_SENESCENCE, DISEASE
Related Pathways	CELLULAR_METABOLISM

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Sirtuins in Neurodegeneration

mechanism · 1084 words

→

Pathway Diagram

graph TD
    SIRTUINS["SIRTUINS"]
    SIRTUINS -->|"catalyzes"| Histone_Deacetylation["Histone Deacetylation"]
    SIRTUINS -->|"modulates"| Ageing["Ageing"]
    SIRTUINS -->|"involved_in"| Cardiovascular_Disease["Cardiovascular Disease"]
    SIRTUINS -->|"regulates"| Cellular_Metabolism["Cellular Metabolism"]
    SIRTUINS -->|"modulates"| DNA_Damage["DNA Damage"]
    SIRTUINS -->|"encodes"| HISTONE_DEACETYLASE["HISTONE_DEACETYLASE"]
    Nad_["Nad+"] -->|"regulates"| SIRTUINS
    TULP3["TULP3"] -->|"activates"| SIRTUINS
    NAD["NAD"] -->|"interacts"| SIRTUINS

Outgoing (15)

Target	Relation	Type	Str
Cardiovascular Disease	involved_in	disease	0.90
Ageing	suppresses	process	0.90
Ageing	modulates	process	0.90
Cellular Metabolism	regulates	process	0.85
DISEASE	implicated_in	disease	0.80
DNA Damage	modulates	process	0.80
AGING	regulates	process	0.80
APOPTOSIS	regulates	phenotype	0.72
HISTONE_DEACETYLASE	encodes	protein	0.72
CARDIOVASCULAR_SYSTEM	expressed_in	cell_type	0.64
OXIDATIVE_STRESS	regulates	phenotype	0.64
CELLULAR_SENESCENCE	regulates	phenotype	0.64
CELLULAR_METABOLISM	regulates	pathway	0.64
DNA_DAMAGE	regulates	phenotype	0.64
CARDIOVASCULAR_DISEASE	associated_with	disease	0.64

Incoming (2)

Source	Relation	Type	Str
TULP3	activates	protein	0.90
NAD+ depletion	inhibits	process	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which specific metabolic pathways in APOE4 microglia are causally linked to dysf

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate identified glycolytic shifts and mTOR disruption but couldn't disting

closed · Rounds: 4 · Score: 0.48 · 2026-04-21

Related Research

Hypotheses and analyses mentioning SIRTUINS in their description or question text

No additional research found