Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about APOPTOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Apoptosis is programmed cell death essential for normal development and tissue homeostasis. In neurodegeneration, aberrant activation of apoptotic pathways contributes to neuronal loss. Key mediators include caspases, Bcl-2 family proteins, cytochrome c, and death receptors. Both intrinsic (mitochondrial) and extrinsic (death receptor) pathways are implicated in diseases like Alzheimer's, Parkinson's, and ALS.
Knowledge base pages for this entity
graph TD
subgraph Pathology["Pathology"]
APOPTOSIS["APOPTOSIS"] -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
APOPTOSIS["APOPTOSIS"] -->|"associated with"| NLRP3["NLRP3"]
APOPTOSIS["APOPTOSIS"] -->|"associated with"| MICROGLIA["MICROGLIA"]
APOPTOSIS["APOPTOSIS"] -->|"associated with"| NEURON["NEURON"]
APOPTOSIS["APOPTOSIS"] -->|"associated with"| APP["APP"]
APOPTOSIS["APOPTOSIS"] -->|"associated with"| GFAP["GFAP"]
BECN1["BECN1"] -->|"associated with"| APOPTOSIS["APOPTOSIS"]
AMYLOID["AMYLOID"] -->|"associated with"| APOPTOSIS["APOPTOSIS"]
end
subgraph Signaling["Signaling"]
APOPTOSIS["APOPTOSIS"] -.->|"inhibits"| CANCER["CANCER"]
APOPTOSIS["APOPTOSIS"] -->|"activates"| Lymphoma["Lymphoma"]
APOPTOSIS["APOPTOSIS"] -->|"activates"| Apoptosis["Apoptosis"]
MITOPHAGY["MITOPHAGY"] -->|"activates"| APOPTOSIS["APOPTOSIS"]
AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| APOPTOSIS["APOPTOSIS"]
AKT["AKT"] -.->|"inhibits"| APOPTOSIS["APOPTOSIS"]
INFLAMMATION["INFLAMMATION"] -->|"activates"| APOPTOSIS["APOPTOSIS"]
end
style APOPTOSIS fill:#5d4400,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style NEURODEGENERATION fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style CANCER fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NLRP3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MICROGLIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style GFAP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Lymphoma fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Apoptosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style BECN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AMYLOID fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MITOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AKT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style INFLAMMATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | causes | phenotype | 1.00 |
| CANCER | inhibits | disease | 1.00 |
| NLRP3 | associated_with | gene | 1.00 |
| MICROGLIA | associated_with | gene | 1.00 |
| NEURON | associated_with | gene | 1.00 |
| APP | associated_with | gene | 1.00 |
| GFAP | associated_with | gene | 1.00 |
| Lymphoma | activates | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| Cardiovascular | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Als | regulates | disease | 1.00 |
| Leukemia | activates | disease | 1.00 |
| Mtor | regulates | pathway | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Leukemia | therapeutic_target | disease | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Angiogenesis | regulates | pathway | 1.00 |
| AUTOPHAGY | inhibits | gene | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Ferroptosis | associated_with | pathway | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| Fibrosis | activates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| Pyroptosis | activates | pathway | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Carcinoma | therapeutic_target | disease | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Apoptosis | expressed_in | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BECN1 | associated_with | gene | 1.00 |
| AMYLOID | associated_with | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| AKT | inhibits | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| BAX | expressed_in | gene | 1.00 |
| ERK | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| BAX | inhibits | gene | 1.00 |
| BAX | activates | gene | 1.00 |
| BAX | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| NLRP3 | activates | gene | 1.00 |
| MIRNAS | therapeutic_target | gene | 1.00 |
| MIRNAS | regulates | gene | 1.00 |
| AUTOPHAGY | inhibits | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| AKT | associated_with | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| NATURAL COMPOUNDS | therapeutic_target | gene | 1.00 |
| MIRNAS | activates | gene | 1.00 |
| ROS | inhibits | gene | 1.00 |
| ROS | regulates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| ERK | inhibits | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| NEUROTOXICITY | activates | gene | 1.00 |
| STROKE | therapeutic_target | gene | 1.00 |
| BAX | regulates | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| STAT3 | activates | gene | 1.00 |
| MITOPHAGY | regulates | gene | 1.00 |
| ERK | therapeutic_target | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| C-JUN | activates | gene | 1.00 |
| AUTOPHAGY | causes | gene | 1.00 |
| ASK1 | regulates | protein | 0.95 |
| Arctiin | inhibits | compound | 0.95 |
| CIRI | causes | disease | 0.95 |
| Mitochondrial Dysfunction | contributes_to | phenotype | 0.95 |
| BPA-BNCT | activates | drug | 0.95 |
| Theranekron | modulates | compound | 0.95 |
| Cordycepin | suppresses | compound | 0.93 |
| MITOCHONDRIA | regulates | cell_type | 0.92 |
| AKT | activates | gene | 0.90 |
| TAU | implicated_in | entity | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-07 | 0 hypotheses
neuroscience | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||