concept

DNA DAMAGE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNA DAMAGE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

294Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

Summary

DNA DAMAGE is a concept in neurodegeneration research. Key relationships include: co discussed, activates, causes. Associated with AMYOTROPHIC LATERAL SCLEROSIS, ATAXIA, CANCER. Connected to 86 entities in the SciDEX knowledge graph.

View on Wiki →

💡 Concept Info

Name	DNA DAMAGE
Key Genes/Proteins	Proteins
Related Diseases	COLORECTAL CANCER, Inflammatory Bowel Disease
Related Pathways	Dna Damage Response, Microrna
Linked Hypotheses	6 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DNA_DAMAGE["<b>DNA DAMAGE</b>"]
    DNA_DAMAGE -->|"causes"| Neuronal_Functions["Neuronal Functions"]
    DNA_DAMAGE -->|"risk_factor_for"| Neurodegeneration["Neurodegeneration"]
    DNA_DAMAGE -->|"contributes to"| Neuronal_Aging["Neuronal Aging"]
    DNA_DAMAGE -->|"modulates"| Chromatin_Topology["Chromatin Topology"]
    DNA_DAMAGE -->|"contributes to"| Follicular_Atresia["Follicular Atresia"]
    DNA_DAMAGE -->|"transports"| T_CELL["T CELL"]
    DNA_DAMAGE -->|"transports"| T_CELLS["T CELLS"]
    DNA_DAMAGE -->|"transports"| TUMOR["TUMOR"]
    DNA_DAMAGE -->|"interacts"| EGF["EGF"]
    DNA_DAMAGE -->|"interacts"| HMGB1["HMGB1"]
    DNA_DAMAGE -->|"activates"| JNK["JNK"]
    miR_139_5p_Mimic["miR-139-5p Mimic"] -->|"causes"| DNA_DAMAGE
    CSNK2A1["CSNK2A1"] -->|"regulates"| DNA_DAMAGE
    NOTCH1["NOTCH1"] -->|"regulates"| DNA_DAMAGE
    oxidative_stress["oxidative stress"] -->|"causes"| DNA_DAMAGE
    Oxidative_Stress["Oxidative Stress"] -->|"causes"| DNA_DAMAGE
    GSK2606414["GSK2606414"] -.protects against.-> DNA_DAMAGE
    TFEB["TFEB"] -->|"inhibits"| DNA_DAMAGE
    TDP_43_mislocalization["TDP-43 mislocalization"] -->|"activates"| DNA_DAMAGE
    CGAS["CGAS"] -->|"causes"| DNA_DAMAGE
    AUTOPHAGY["AUTOPHAGY"] -->|"transports"| DNA_DAMAGE
    CANCER["CANCER"] -->|"transports"| DNA_DAMAGE

Outgoing (78)

Target	Relation	Type	Str
Neuronal Functions	causes	phenotype	0.95
Transcription	inhibits	process	0.95
Transcription	associated_with	process	0.95
Neurodegeneration	risk_factor_for	disease	0.95
Neuronal Aging	contributes_to	process	0.90
Neuronal Aging	risk_factor_for	process	0.90
cGAS-STING signaling	activates	pathway	0.90
STING Pathway	activates	pathway	0.90
p53 Phosphorylation	activates	process	0.90
neuropathology	contributes_to	disease	0.90
Neuroinflammation	contributes_to	process	0.90
aging	promotes	process	0.90
KIAA0247	upregulates	gene	0.90
APOPTOSIS	promotes	process	0.90
Apoptosis	contributes_to	process	0.90
STING pathway	activates	pathway	0.87
Chromatin Topology	modulates	process	0.85
Chromatin Topology	associated_with	mechanism	0.85
ribosome biogenesis	modulates	process	0.85
STING	activates	protein	0.85
Brain Aging	contributes_to	process	0.85
Genome Instability	associated_with	phenotype	0.85
Neuroinflammation	contributes_to	process	0.85
Aging	contributes_to	process	0.85
Follicular Atresia	contributes_to	process	0.80
Motor Neuron Death	causes	process	0.80
cGAS	induces	protein	0.80
Neurodegeneration	contributes_to	process	0.80
NEURODEGENERATION	contributes_to	process	0.80
Aging	causes	process	0.80
oligodendrocyte degeneration	causes (DNA damage in oligodendrocytes precedes amyloid pa)	mechanism	0.75
Parkinson's disease	associated_with	disease	0.70
Dna Damage Response	regulates	pathway	0.50
Tumor Microenvironment	activates	process	0.50
Epithelial-Mesenchymal Transition	activates	process	0.50
COLORECTAL CANCER	activates	disease	0.50
Microrna	activates	pathway	0.50
Inflammatory Bowel Disease	activates	disease	0.50
Reactive Oxygen Species	activates	process	0.50
RAPAMYCIN	activates	concept	0.50
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
PEROXISOME	activates	concept	0.50
CHRONIC INFLAMMATION	activates	concept	0.50
Proteins	associated_with	protein	0.50
Dna Damage Response	activates	pathway	0.50
MOTOR NEURON	activates	concept	0.50
HOMOLOGOUS RECOMBINATION	activates	concept	0.50
BREAST CANCER	activates	disease	0.50
Microrna	regulates	pathway	0.50

Incoming (216)

Source	Relation	Type	Str
SMARCAL1	inhibits	gene	0.95
etoposide	causes	drug	0.95
miR-139-5p Mimic	causes	compound	0.90
SNCA	causes	protein	0.90
Top1 Cleavage Complexes	contributes_to	mechanism	0.90
cigarette smoke	causes	phenotype	0.90
R-Loop	causes	mechanism	0.90
PRMT suppression	promotes	process	0.90
Prmt Inhibition	upregulates	mechanism	0.90
PRMT inhibition	associated_with	process	0.88
CSNK2A1	regulates	protein	0.85
NOTCH1	regulates	protein	0.85
Redox Stress	causes	process	0.85
SNCA	causes	gene	0.85
Single-Stranded DNA	associated_with	compound	0.85
GABARAPL1	protects_against	gene	0.85
PARP1	involved_in	protein	0.85
Single-Stranded Dna	associated_with	compound	0.85
SOD1	associated_with	protein	0.85
SOD1 Aggregation	contributes_to	process	0.85
SNCA	causes	protein	0.85
R-Loop Deregulation	contributes_to	mechanism	0.85
Oxidative Stress	causes	process	0.85
Alpha-Synuclein	causes	protein	0.85
Aging	causes	process	0.85
Helicobacter pylori	associated_with	entity	0.80
PARP1	activates	gene	0.80
PARP1	traps	gene	0.80
SIRTUINS	modulates	protein	0.80
HERV-K	causes	gene	0.80
GSK2606414	protects_against	drug	0.70
TFEB	inhibits	protein	0.70
TDP-43 mislocalization	activates	process	0.70
oxidative stress	causes	process	0.70
Oxidative Stress	causes	process	0.70
Autophagy	activates	process	0.50
cancer	activates	disease	0.50
TUMOR	activates	disease	0.50
Stem Cell	activates	cell_type	0.50
LRRK2	activates	gene	0.50
Pi3K	activates	pathway	0.50
TFEB	activates	protein	0.50
EGFR	activates	gene	0.50
EIF2A	activates	protein	0.50
STING1	activates	protein	0.50
RICTOR	activates	gene	0.50
EIF2AK3	activates	gene	0.50
DDIT3	activates	gene	0.50
MLKL	activates	gene	0.50
OPTN	activates	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su	0.562	neurodegeneration	What upstream mechanisms trigger p53 act

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.527

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DNA DAMAGE

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Novel Therapy Index

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

Alzheimer's Disease Mechanism Index

Therapeutics

NPM1 Gene

neuroinflammation

NRF2 Oxidative Stress Pathway

Frontotemporal Dementia (FTD)

Mitochondrial Dysfunction in Parkinson's Disease

Synucleinopathy Mechanism

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

oxidative-stress-comparison

Mitophagy Pathway in Neurodegeneration

University of Heidelberg

Vascular Cognitive Impairment (VCI)

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Coenzyme Q10 for Neurodegeneration