Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC6A12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Betaine/GABA transporter (BGT1) gene - involved in GABAergic neurotransmission and osmotic regulation
| Gene Symbol | SLC6A12 |
| Full Name | SLC6A12 |
| Aliases | Betaine/GABA transporter (BGT1) gene |
| Chromosome | 12p12.1 |
| Protein Type | Gene |
| Function | is a member of the neurotransmitter symporter family (SLC6) and plays crucial roles in both GABAergic neurotransmission and cellular osmotic balance. |
| Primary Expression | various tissues, with highest expression in kidney and moderate expression in brain, where it contributes to the maintenance of inhibitory neurotransm |
| Molecular Weight | 70 kDa |
| Amino Acids | 614 aa |
| Exons | 16 |
| NCBI Gene ID | Search NCBI |
| GeneCards | SLC6A12 |
| Human Protein Atlas | SLC6A12 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, Epilepsy |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
SLC6A12["SLC6A12"]
neurodegeneration["neurodegeneration"]
SLC6A12 -->|"implicated_in"| neurodegeneration
style SLC6A12 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||