Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SMAD2/3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| RelA/p300 at NF-κB promoters | displaces | mechanism | 0.70 |
| RelA/p300 coactivator complex | associated_with | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NLRC5 | activates | protein | 0.85 |
| TGFBR1/TGFBR2 | activates | protein | 0.70 |
| TGF-β1 | activates | protein | 0.70 |
| SMAD7 | inhibits | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TGF-β1–SMAD2/3 Axis as Master Suppressor of Microglial Train | 0.712 | neuroinflammation | What specific astrocyte-derived factors |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.712
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning SMAD2/3 in their description or question text
No additional research found