gene

NLRC5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLRC5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

85Connections

0Hypotheses

0Analyses

50Outgoing

34Incoming

Summary

NLRC5 is the largest NLR family member, regulating MHC class I expression and innate immunity, with roles in neuroinflammation and neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	NLRC5
Full Name	NLR Family CARD Domain Containing 5
Chromosome	16q13
Protein Family	NLR (NOD-like receptor) family
Function	regulating MHC class I expression and innate immunity
Primary Expression	Ubiquitous, high in immune cells
Molecular Weight	220 kDa
Amino Acids	2000 aa
Pathways	NF-κB
UniProt ID	[Q86TI2](https://www.uniprot.org/uniprot/Q86TI2)
Ensembl ID	ENSG00000148488
OMIM	613851
GeneCards	NLRC5
Human Protein Atlas	NLRC5
Associated Diseases	Infectious Disease, Inflammatory Disease
Known Drugs/Compounds	Heme, PAMP
Interactions	CD8, IRF1, CIITA, NPM1, NLRP12, Panoptosome
KG Connections	85 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NLRC5["<b>NLRC5</b>"]
    Cancer{"Cancer"}
    NLRC5 -->|"activates"| Cancer
    Ms{"Ms"}
    NLRC5 -->|"activates"| Ms
    Tumor{"Tumor"}
    NLRC5 -->|"activates"| Tumor
    NLRC5 -->|"interacts with"| Ms
    CD8["CD8"]
    NLRC5 -->|"activates"| CD8
    IRF1["IRF1"]
    NLRC5 -->|"activates"| IRF1
    CIITA["CIITA"]
    NLRC5 -->|"activates"| CIITA
    DNA["DNA"]
    NLRC5 -->|"activates"| DNA
    NPM1["NPM1"]
    NLRC5 -->|"activates"| NPM1
    NLRP12["NLRP12"]
    NLRC5 -->|"interacts with"| NLRP12
    CYTOKINES["CYTOKINES"]
    NLRC5 -->|"associated with"| CYTOKINES
    TLR["TLR"]
    NLRC5 -->|"interacts with"| TLR
    IRF1 -->|"binds"| NLRC5
    NPM1 -->|"activates"| NLRC5
    CD8 -->|"activates"| NLRC5
    CIITA -->|"activates"| NLRC5
    IRF1 -->|"activates"| NLRC5
    DNA -->|"activates"| NLRC5
    style NLRC5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (51)

Target	Relation	Type	Str
PANoptosis	promotes	process	0.95
inflammatory cell death	regulates	process	0.90
innate immune response	activates	process	0.90
Panoptosome	interacts_with	protein	0.90
Smad2/3	activates	pathway	0.85
Inflammatory Disease	associated_with	disease	0.85
Infectious Disease	associated_with	disease	0.85
inflammatory cell death	senses	process	0.80
MHC-I	regulates	protein	0.80
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	interacts_with	disease	0.65
Inflammation	regulates	disease	0.65
Breast Cancer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
CD8	activates	gene	0.60
IRF1	activates	gene	0.60
CIITA	activates	gene	0.60
NPM1	activates	gene	0.60
NLRP12	interacts_with	gene	0.60
DNA	activates	gene	0.60
CYTOKINES	associated_with	gene	0.60
TLR	interacts_with	gene	0.60
MHC-I	activates	gene	0.60
CANCER	activates	gene	0.60
Autophagy	regulates	pathway	0.60
Mitophagy	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
Inflammasome	regulates	pathway	0.60
Metastasis	inhibits	pathway	0.60
Checkpoint Inhibitor	inhibits	pathway	0.60
Immune Response	inhibits	pathway	0.60
Immune Checkpoint	inhibits	pathway	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
T Cell	activates	cell_type	0.60
NLR	interacts_with	gene	0.60
NAD	associated_with	gene	0.60
AND	interacts_with	gene	0.60
Cytokine	causes	protein	0.60
Ras	activates	protein	0.60
T Cell	expressed_in	cell_type	0.55
NLRP12	co_expressed_with	gene	0.50
CHIP	activates	protein	0.50
TUMOR	activates	disease	0.50
disease	interacts_with	disease	0.50
CELL DEATH	interacts_with	concept	0.50
CYTOKINE	associated_with	concept	0.50
CELL DEATH	causes	concept	0.50

Incoming (34)

Source	Relation	Type	Str
USP14	promotes	protein	0.90
Heme	activates	compound	0.90
PAMP	activates	compound	0.90
TLR signaling	upstream_of	pathway	0.85
PAMP/heme	activates	process	0.85
IRF1	binds	protein	0.80
CIITA	activates	gene	0.70
NPM1	activates	gene	0.60
CD8	activates	gene	0.60
IRF1	activates	gene	0.60
CDK5	inhibits	gene	0.60
STAT1	inhibits	gene	0.60
CD8	inhibits	gene	0.60
DNA	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
GENES	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MHC-I	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
CANCER	activates	gene	0.60
AND	activates	gene	0.60
MHC-I	activates	gene	0.60
NAD	associated_with	gene	0.60
RNA	activates	gene	0.60
AND	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
TLR	interacts_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
NLR	regulates	gene	0.60
NLRP12	interacts_with	gene	0.50
NLR	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NLRC5

Understanding Entity Pages

Summary

Wiki Pages (9)

NLRC5 — NLR Family CARD Domain Containing 5

NPM1 Gene

nlrc5-protein

Gasotransmitters in Neuroprotection - AD/PD

USP14 Gene

Class II Major Histocompatibility Complex Transactivator

IRF1 Gene - Interferon Regulatory Factor 1