SMAD7

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMAD7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

SMAD7 (SMAD Family Member 7) - an inhibitory SMAD that negatively regulates TGF-β/BMP signaling. Associated with fibrosis, inflammatory bowel disease, cancer, and neurodegenerative diseases including Alzheimer's and Parkinson's.

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graph TD
    SMAD7["<b>SMAD7</b>"]
    Fibrosis{"Fibrosis"}
    SMAD7 -->|"inhibits"| Fibrosis
    TGF___signaling(["TGF-beta signaling"])
    SMAD7 -->|"inhibits"| TGF___signaling
    SMAD2_3_phosphorylation(["SMAD2/3 phosphorylation"])
    SMAD7 -->|"inhibits"| SMAD2_3_phosphorylation
    neuroinflammation(["neuroinflammation"])
    SMAD7 -->|"activates"| neuroinflammation
    apoptosis(["apoptosis"])
    SMAD7 -->|"activates"| apoptosis
    postoperative_cognitive_dysfunction{"postoperative cognitive dysfunction"}
    SMAD7 -->|"associated with"| postoperative_cognitive_dysfunction
    hippocampus["hippocampus"]
    SMAD7 -->|"expressed in"| hippocampus
    TGF__(["TGF-beta"])
    SMAD7 -->|"inhibits"| TGF__
    SMAD2_3["SMAD2/3"]
    SMAD7 -->|"inhibits"| SMAD2_3
    Tumor{"Tumor"}
    SMAD7 -->|"regulates"| Tumor
    Ms{"Ms"}
    SMAD7 -->|"regulates"| Ms
    UBIQUITIN["UBIQUITIN"]
    SMAD7 -->|"regulates"| UBIQUITIN
    FIP200["FIP200"]
    FIP200 -->|"regulates"| SMAD7
    MIRNAS["MIRNAS"]
    MIRNAS -->|"regulates"| SMAD7
    WIPI2["WIPI2"]
    WIPI2 -->|"activates"| SMAD7
    style SMAD7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0