Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SMAD7PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SMAD Family Member 7 is a SMAD family (inhibitory) member. The protein contains the characteristic domain structure including domain descriptions.
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| Gene Symbol | SMAD7PROTEIN |
| Chromosome | 18q21.1 |
| Function | is a SMAD family (inhibitory) member. |
| Subcellular Localization | ** | Cytoplasm, nucleus, plasma membrane | |
| Molecular Weight | 46 kDa |
| GeneCards | SMAD7PROTEIN |
| Human Protein Atlas | SMAD7PROTEIN |
| Associated Diseases | postoperative cognitive dysfunction |
| Interactions | CANCER, CDKN1A, ESRRB, GBM, JUN, MLCK |
| KG Connections | 64 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SMAD7PROTEIN["SMAD7PROTEIN"]
neurodegeneration["neurodegeneration"]
SMAD7PROTEIN -->|"implicated_in"| neurodegeneration
style SMAD7PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity