gene

GBM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GBM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1411Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

GBM is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with AD, ALI, ALS. Connected to 637 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GBM
Full Name	Glioma-Associated Oncogene Homolog
Chromosome	3p25.1
Protein Family	C2H2-type zinc finger transcription factors
Exons	14
Pathways	Amyloid, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt ID	P08151
NCBI Gene ID	2735
Ensembl ID	ENSG00000087495
GeneCards	GBM
Human Protein Atlas	GBM
Chromosomal location	3p25.1
Exon count	14 exons
Alternative splicing	Produces full-length activator (GLI3A) and truncated repressor (GLI3R)
Promoter architecture	Contains GLI-binding sites that enable autoregulation
Associated Diseases	AD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compounds	quercetin, SSRI
Interactions	SOAT1, DGAT1, STING, CGAS, RAC1, PAK1
KG Connections	1411 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GBM — AlphaFold P08151 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

GLI Gene Family

gene · 2171 words

→

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

biomarker · 3602 words

→

AAIC 2026: Combination Therapy and Multi-Target Approaches in Alzheimer's Disease

event · 2892 words

→

Pathway Diagram

flowchart TD
    GBM(["GBM"])
    Glioblastoma["Glioblastoma"]
    Tumor["Tumor"]
    GLIOBLASTOMA(["GLIOBLASTOMA"])
    Cancer["Cancer"]
    Als["Als"]
    CANCER(["CANCER"])
    GENES(["GENES"])

    GBM -->|"associated with"| Glioblastoma
    GBM -->|"activates"| Tumor
    GBM -->|"therapeutic target"| Glioblastoma
    GBM -->|"associated with"| Tumor
    GBM -->|"associated with"| GLIOBLASTOMA
    GBM -->|"therapeutic target"| GLIOBLASTOMA
    GBM -->|"activates"| Cancer
    GBM -->|"associated with"| Cancer
    GBM -->|"therapeutic target"| Tumor
    GBM -->|"therapeutic target"| Cancer
    GBM -->|"regulates"| Als
    GBM -->|"activates"| Glioblastoma
    GBM -->|"activates"| CANCER
    GBM -->|"activates"| GLIOBLASTOMA
    GBM -->|"associated with"| GENES

    style GBM fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (956)

Target	Relation	Type	Str
Glioblastoma	associated_with	disease	1.00
Tumor	activates	disease	1.00
Glioblastoma	therapeutic_target	disease	1.00
Tumor	associated_with	disease	1.00
GLIOBLASTOMA	associated_with	gene	1.00
GLIOBLASTOMA	therapeutic_target	gene	1.00
Cancer	activates	disease	0.95
Cancer	associated_with	disease	0.95
Tumor	therapeutic_target	disease	0.95
Cancer	therapeutic_target	disease	0.95
Als	regulates	disease	0.95
Glioblastoma	activates	disease	0.95
glioblastoma	treats	disease	0.90
glioblastoma	regulates	disease	0.90
glioblastoma	associated_with	disease	0.90
blood-brain barrier	expressed_in	brain_region	0.90
glioblastoma	implicated_in	disease	0.90
glioblastoma	biomarker_for	disease	0.90
stem cells	expressed_in	cell_type	0.90
oxidative stress response	participates_in	pathway	0.90
T cells	expressed_in	cell_type	0.90
glioblastoma	targets	disease	0.90
blood-brain barrier	participates_in	pathway	0.90
neural stem cells	regulates	cell_type	0.90
CANCER	activates	gene	0.90
GLIOBLASTOMA	activates	gene	0.90
GENES	associated_with	gene	0.90
CANCER	associated_with	gene	0.90
Als	activates	disease	0.85
Glioblastoma	regulates	disease	0.85
Glioma	activates	disease	0.85
Glioma	therapeutic_target	disease	0.85
Glioblastoma	expressed_in	disease	0.85
Aging	therapeutic_target	disease	0.85
MS4A6A	activates	gene	0.80
glioblastoma	interacts_with	disease	0.80
lipid metabolism	participates_in	pathway	0.80
PI3K-AKT-mTOR signaling	participates_in	pathway	0.80
macrophages	inhibits	cell_type	0.80
unfolded protein response	participates_in	pathway	0.80
microglia	inhibits	cell_type	0.80
neural stem cells	activates	cell_type	0.80
neural stem cells	associated_with	cell_type	0.80
AKT	activates	gene	0.80
Blood-Brain Barrier	therapeutic_target	pathway	0.80
CANCER	therapeutic_target	gene	0.80
GLIOBLASTOMA	expressed_in	gene	0.80
GENES	activates	gene	0.80
Invasion	associated_with	pathway	0.80
Tumor	biomarker_for	disease	0.75

Incoming (455)

Source	Relation	Type	Str
EGFR	activates	gene	0.90
PI3K	activates	gene	0.80
TGF-β	associated_with	pathway	0.70
PI3K	therapeutic_target	gene	0.70
PTEN	associated_with	gene	0.70
TP53	associated_with	gene	0.70
EGFR	associated_with	gene	0.70
CDKN2A	associated_with	gene	0.70
PTEN	activates	gene	0.70
STAT3	therapeutic_target	gene	0.70
PI3K/AKT/MTOR	regulates	pathway	0.70
Wnt	associated_with	pathway	0.70
FN1	regulates	gene	0.70
DNA	therapeutic_target	gene	0.70
ERK	activates	gene	0.70
VAMP8	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
BMAL1	activates	gene	0.60
CLOCK	regulates	gene	0.60
RAB32	associated_with	gene	0.60
DRP1	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
C1QA	associated_with	gene	0.60
C1QC	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SDC1	associated_with	gene	0.60
P62	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
STX17	associated_with	gene	0.60
TGM2	associated_with	gene	0.60
EPG5	associated_with	gene	0.60
LC3	associated_with	gene	0.60
DGAT1	activates	gene	0.60
C3AR1	expressed_in	gene	0.60
ANXA2	regulates	gene	0.60
MTOR	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
BCL2	activates	gene	0.60
ATG5	activates	gene	0.60
ATG16L1	activates	gene	0.60
ELP3	activates	gene	0.60
PI3K	inhibits	gene	0.60
SNAP29	inhibits	gene	0.60
STX17	inhibits	gene	0.60
AKT	inhibits	gene	0.60
DNM1L	inhibits	gene	0.60
FIS1	inhibits	gene	0.60
MFF	regulates	gene	0.60
PRKDC	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GBM

Understanding Entity Pages

Summary

Wiki Pages (21)

GLI Gene Family

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

AAIC 2026: Combination Therapy and Multi-Target Approaches in Alzheimer's Disease

SIGLEC9 — Sialic Acid Binding Ig-Like Lectin 9

Wnt Signaling Dysfunction in Neurodegenerative Diseases

Combination Therapy Approaches in Neurodegenerative Disease

VAMP8 — Vesicle Associated Membrane Protein 8

STX17 Gene

diaph3

TGM2 — Transglutaminase 2

KCNH7 Gene

WWTR1 (TAZ) — WW Domain Containing Transcription Regulator 1, Hippo Effector

RAB32 Gene

Focused Ultrasound for Drug Delivery to Brain

DGAT1 — Diacylglycerol O-Acyltransferase 1

Tumor Necrosis Factor (TNF)

OTUD4 — OTU Deubiquitinase 4

JAK3 Gene

ELP3 Gene