gene

CDKN1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDKN1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

474Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Cell cycle regulator with critical roles in neuronal survival, DNA damage response, and neurodegeneration

View on Wiki →

🧬 Gene Info

Gene Symbol	CDKN1A
Full Name	Cyclin-Dependent Kinase Inhibitor 1A
Chromosome	6p21.31
Function	is a key cell cycle regulator that mediates p53-dependent cell cycle arrest.
Amino Acids	164 aa
Pathways	TGF-β
UniProt ID	P38936
NCBI Gene ID	1026
Ensembl ID	ENSG00000100994
GeneCards	CDKN1A
Human Protein Atlas	CDKN1A
N-terminal domain	binds and inhibits CDK2/cyclin E and CDK1/cyclin B complexes
C-terminal domain	interacts with PCNA (proliferating cell nuclear antigen), blocking DNA replication
p53-binding region	contains p53-responsive elements for transcriptional activation
Neurons	particularly in post-mitotic differentiated neurons
Associated Diseases	ALS, Aging, Alzheimer, Cancer, Cellular Senescence
Known Drugs/Compounds	rapamycin
Interactions	BECN1, CAT, ACTB, CTSD, GAPDH, ATG5
KG Connections	471 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CDKN1A — AlphaFold P38936 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CDKN1A["CDKN1A"] -->|"regulates"| Senescence["Senescence"]
    CDKN1A["CDKN1A"] -->|"regulates"| Ms["Ms"]
    CDKN1A["CDKN1A"] -->|"regulates"| Autism["Autism"]
    CDKN1A["CDKN1A"] -->|"associated"| Als["Als"]
    CDKN1A["CDKN1A"] -->|"associated"| Ms_1["Ms"]
    CDKN1A["CDKN1A"] -->|"therapeutic target"| Ms_2["Ms"]
    CYCS["CYCS"] -.->|"inhibits"| CDKN1A["CDKN1A"]
    CD4["CD4"] -->|"interacts"| CDKN1A["CDKN1A"]
    MAPK3["MAPK3"] -->|"interacts"| CDKN1A["CDKN1A"]
    ZAP70["ZAP70"] -->|"interacts"| CDKN1A["CDKN1A"]
    style CDKN1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (295)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Senescent Cells	expressed_in	cell_type	0.95
Autophagosome	associated_with	cell_type	0.90
Cellular Senescence	associated_with	phenotype	0.90
Alzheimer'S Disease	therapeutic_target	disease	0.88
Proliferative Arrest	inhibits	process	0.85
Proliferative Arrest	causes	process	0.85
Pulmonary Vascular Endothelial Cell Senescence	biomarker_for	process	0.85
Senescence	biomarker_for	process	0.80
Cellular Senescence	biomarker_for	process	0.80
ROS	activates	gene	0.80
Senescence	regulates	disease	0.75
Cancer	activates	disease	0.75
Als	activates	disease	0.75
P62	regulates	gene	0.70
Mapk	therapeutic_target	pathway	0.70
P21	inhibits	gene	0.70
GENES	regulates	gene	0.70
CANCER	activates	gene	0.70
Spinal Muscular Atrophy	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Autism	regulates	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
Infection	regulates	disease	0.65
Als	regulates	disease	0.65
Viral Infection	regulates	disease	0.65
Aging	activates	disease	0.65
Tumor	activates	disease	0.65
Prostate Cancer	activates	disease	0.65
Breast Cancer	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Senescence	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Ataxia	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Senescence	inhibits	disease	0.65

Incoming (179)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
SQSTM1	mediates	protein	0.95
Mir-302B	targets	biomarker	0.90
XHP	upregulates	drug	0.90
MIR-302B	targets	gene	0.90
Polygonatum Sibiricum Polysaccharide	downregulates	compound	0.85
SIRT1	downregulates	protein	0.85
Autophagy Deficiency	causes	phenotype	0.85
Xiyangshen Sanqi Danshen Granules	downregulates	drug	0.80
telomere shortening	upregulates	phenotype	0.80
SQSTM1	binds_to	gene	0.80
MAPK3	therapeutic_target	gene	0.70
MIRNAS	regulates	gene	0.70
P53	activates	gene	0.70
CYCS	inhibits	gene	0.60
CD4	interacts_with	gene	0.60
MAPK3	interacts_with	gene	0.60
ZAP70	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
CD19	interacts_with	gene	0.60
EEF2	interacts_with	gene	0.60
CCL5	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
TLR7	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
RAC2	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
CDK4	interacts_with	gene	0.60
SCARB2	associated_with	gene	0.60
UBE2D1	associated_with	gene	0.60
LGALS1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
BCL2L1	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
SRC	therapeutic_target	gene	0.60
CYCS	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
HSP90AA1	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
CASP3	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
CDK4	therapeutic_target	gene	0.60
SOD2	activates	gene	0.60
GADD45B	activates	gene	0.60
CDKN2A	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
BECN1	inhibits	gene	0.60
ATG5	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CDKN1A

Understanding Entity Pages

Summary

Wiki Pages (21)

CDKN1A — Cyclin-Dependent Kinase Inhibitor 1A

FOXO1 Protein

Cellular Senescence in Neurodegeneration

Longevity and Rejuvenation Therapies Landscape

FOXO4 — Forkhead Box O4

Cellular Senescence in Neurodegeneration

Astrocyte Senescence Pathway in Neurodegeneration

CBS Microglial Neuroimmune Axis

Cyclin E2 (CCNE2) Protein

Cellular Senescence Hypothesis in Parkinson's Disease

Cellular Senescence in Corticobasal Syndrome

TYRO3 - TYRO3 Receptor Tyrosine Kinase

PRDM4 Gene

cellular-senescence-4r-tauopathies

MAF - MAFA BZIP Transcription Factor

[p53](/proteins/tp53) Pathway in [Parkinson](/diseases/parkinsons-disease)'s Disease

GADD45G — Growth Arrest And DNA Damage Inducible Gamma

Cellular Senescence Disease Comparison

DCLRE1A Gene