Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SOX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SRY-Box Transcription Factor 1 involved in neural development, GABAergic neuron specification, and neurodegenerative disease pathogenesis
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| Gene Symbol | SOX1 |
| Full Name | SRY-Box Transcription Factor 1 |
| Chromosome | 13q34 |
| Protein Family | SOX family (Sry-related HMG box) |
| Protein Type | Transcription Factor |
| Function | is a member of the SRY-related HMG-box (SOX) family of transcription factors that play critical roles in embryonic development, cell fate determination, and tissue-specific differentiation. |
| Primary Expression | neural progenitor cells and maintains stem cell identity through direct regulation of neural stem cell markers and repression of alternative cell fate |
| Subcellular Localization | Nucleus |
| Molecular Weight | 39 kDa |
| Amino Acids | 372 aa |
| Gene Type | Protein coding |
| UniProt ID | P35746 |
| NCBI Gene ID | 6656 |
| Ensembl ID | ENSG00000113645 |
| OMIM | 184757 |
| GeneCards | SOX1 |
| Human Protein Atlas | SOX1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SOX1["SOX1"]
neurodegeneration["neurodegeneration"]
SOX1 -->|"implicated_in"| neurodegeneration
style SOX1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SOX1 in their description or question text
No additional research found