gene 697 words KG: SOX10 2026-03-12
kind:genesection:genesstate:published
Contents

SOX10 Gene

🧬 Gene Info
Gene SymbolSOX10
Chromosome22q13.1
Protein TypeTranscription Factor
Functionis a critical transcription factor for neural crest development and glial cell differentiation.
Amino Acids446 aa
Exons3
UniProt IDP56937
NCBI Gene ID6663
Ensembl IDENSG00000100146
GeneCardsSOX10
Human Protein AtlasSOX10
GeneFunction
MBPMyelin Basic Protein
PLP1Proteolipid Protein
PMP22Peripheral Myelin Protein
Associated DiseasesAls, Tumor
InteractionsFUS, GDNF, FGF2, CHAT, P53, AND
KG Connections51 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Oligodendrocyte White Matter Vulnerability
Score: 0.40

Related Analyses (7)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
NESTIN: Intermediate Filament Protein in Neural Stem Ce
gene · KG edge: activates
MPZ — Myelin Protein Zero
gene · KG edge: interacts_with
MBP - Myelin Basic Protein
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

SOX10 expressed_in DISC1
SOX10 expressed_in MBP
SOX10 associated_with NF1
SOX10 associated_with CDKN2A
SOX10 activates FUS
SOX10 activates GDNF
SOX10 activates FGF2
SOX10 expressed_in SOX2
SOX10 activates CHAT
SOX10 causes TCF4