gene 911 words KG: SOX11 2026-03-26
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

SOX11 — SRY-Box Transcription Factor 11

🧬 Gene Info
Gene SymbolSOX11
Full NameSRY-Box Transcription Factor 11
Chromosome2p25.2
Protein TypeTranscription Factor
Functionis a member of the SOX (SRY-related HMG-box) family of transcription factors that play essential roles in neural development, neuronal differentiation, and cell fate specification.
Amino Acids497 aa
PathwaysEpigenetic
UniProt ID[P35746](https://www.uniprot.org/uniprot/P35746)
Ensembl IDENSG00000175087
GeneCardsSOX11
Human Protein AtlasSOX11
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsMYC, AND, CYCLIN D1
KG Connections16 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.41

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (6)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown
validation · proposed · Score: 0.40

See Also (14)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: therapeutic_target
TP53 Gene
gene · KG edge: therapeutic_target
SMARCA4
gene · KG edge: therapeutic_target
NSD2 (Nuclear Receptor Binding SET Domain Protein 2)
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

SOX11 activates MYC
SOX11 therapeutic_target KMT2D
SOX11 therapeutic_target NSD2
SOX11 therapeutic_target NOTCH2
SOX11 therapeutic_target NFKBIE
SOX11 therapeutic_target CDKN2A
SOX11 therapeutic_target SMARCA4
SOX11 activates AND
SOX11 activates CYCLIN D1
SOX11 therapeutic_target Aging