protein

STATHMIN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STATHMIN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections
0Hypotheses
0Analyses
4Outgoing
3Incoming

No summary available yet. View on Wiki →

🔬 Protein Info
Gene SymbolSTATHMIN2
Functionis a hallmark of TDP-43-dependent neurodegeneration.
GeneCardsSTATHMIN2
Human Protein AtlasSTATHMIN2
Associated Diseasesneurodegeneration
KG Connections7 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Stathmin-2 (SCG10)

protein · 3087 words

Therapeutic Safety Adverse Event Investment Synthesis

mechanism · 1971 words

c9orf72-als-ftd-phenotype-mechanism

general · 972 words

TDP-43 Protein

redirect · 697 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    STATHMIN2(["STATHMIN2"])
    style STATHMIN2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    TDP43(["TDP43"])
    Premature_Polyadenylation(["Premature Polyadenylation"])
    Axonal_Regeneration(["Axonal Regeneration"])
    Motor_Neurons(["Motor Neurons"])
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    Neuronal_Growth(["Neuronal Growth"])
    neurodegeneration["neurodegeneration"]

    TDP43 -->|"regulates"| STATHMIN2
    Premature_Polyadenylation -.->|"downregulates"| STATHMIN2
    STATHMIN2 -->|"promotes"| Axonal_Regeneration
    STATHMIN2 -->|"expressed_in"| Motor_Neurons
    TDP43 -->|"binds"| STATHMIN2
    STATHMIN2 -->|"biomarker_for"| Amyotrophic_Lateral_Sclerosis
    STATHMIN2 -->|"promotes"| Neuronal_Growth
    STATHMIN2 -->|"implicated_in"| neurodegeneration

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class TDP43 protein
    class Premature_Polyadenylation protein
    class Axonal_Regeneration protein
    class Motor_Neurons protein
    class Amyotrophic_Lateral_Sclerosis disease
    class Neuronal_Growth protein
    class neurodegeneration disease

Outgoing (4)

TargetRelationTypeStr
Axonal Regenerationpromotesprocess0.90
Motor Neuronsexpressed_incell_type0.90
Amyotrophic Lateral Sclerosisbiomarker_fordisease0.85
Neuronal Growthpromotesprocess0.80

Incoming (3)

SourceRelationTypeStr
TDP43regulatesprotein0.95
Premature Polyadenylationdownregulatesmechanism0.95
TDP43bindsprotein0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found