Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STATHMIN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | STATHMIN2 |
| Function | is a hallmark of TDP-43-dependent neurodegeneration. |
| GeneCards | STATHMIN2 |
| Human Protein Atlas | STATHMIN2 |
| Associated Diseases | neurodegeneration |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
STATHMIN2(["STATHMIN2"])
style STATHMIN2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
TDP43(["TDP43"])
Premature_Polyadenylation(["Premature Polyadenylation"])
Axonal_Regeneration(["Axonal Regeneration"])
Motor_Neurons(["Motor Neurons"])
Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
Neuronal_Growth(["Neuronal Growth"])
neurodegeneration["neurodegeneration"]
TDP43 -->|"regulates"| STATHMIN2
Premature_Polyadenylation -.->|"downregulates"| STATHMIN2
STATHMIN2 -->|"promotes"| Axonal_Regeneration
STATHMIN2 -->|"expressed_in"| Motor_Neurons
TDP43 -->|"binds"| STATHMIN2
STATHMIN2 -->|"biomarker_for"| Amyotrophic_Lateral_Sclerosis
STATHMIN2 -->|"promotes"| Neuronal_Growth
STATHMIN2 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class TDP43 protein
class Premature_Polyadenylation protein
class Axonal_Regeneration protein
class Motor_Neurons protein
class Amyotrophic_Lateral_Sclerosis disease
class Neuronal_Growth protein
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| Axonal Regeneration | promotes | process | 0.90 |
| Motor Neurons | expressed_in | cell_type | 0.90 |
| Amyotrophic Lateral Sclerosis | biomarker_for | disease | 0.85 |
| Neuronal Growth | promotes | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TDP43 | regulates | protein | 0.95 |
| Premature Polyadenylation | downregulates | mechanism | 0.95 |
| TDP43 | binds | protein | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||