protein

TDP43

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP43: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

252Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

TDP43 is a protein involved in neurodegeneration research. Key relationships include: associated with, causes, biomarker for. Associated with ALS, Als, Alzheimer. Connected to 73 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	TDP
Full Name	43 (TAR DNA-Binding Protein 43) — Biomarker
Aliases	TDP43
Chromosome	1p36.
Function	TDP-43 is central to the pathogenesis of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and is commonly co-detected in Alzheimer's disease as a secondary pathology.
Subcellular Localization	signal (
UniProt ID	Q7J653
GeneCards	TDP
Human Protein Atlas	TDP
Gene	TARDBP (chromosome 1p36.22)
Protein	TDP-43, ~43 kDa
Sample Types	CSF, plasma, serum
Key Diseases	ALS, FTD, LATE, AD
CSF Sensitivity (ALS)	70-90%
CSF Specificity (ALS vs. controls)	80-90%
Associated Diseases	ALS, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Dementia
Interactions	GFAP, AKT, RAN, G3BP1, Rb, DNA
KG Connections	251 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TDP43 — AlphaFold Q13148 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TDP43["TDP-43 Protein"] -->|"Normally in"| Nucleus["Nucleus"]
    TDP43 -->|"Regulates"| RNA["RNA Splicing and Stability"]
    Stress["Cellular Stress"] -->|"Causes"| Mislocalization["Cytoplasmic Mislocalization"]
    Mislocalization -->|"Forms"| Aggregates["Cytoplasmic Aggregates"]
    Aggregates -->|"Loss of"| Function["Nuclear Function"]
    Aggregates -->|"Gain of"| Toxicity["Cytoplasmic Toxicity"]
    TDP43 -.Pathology found in.-> ALS["ALS"]
    TDP43 -.Pathology found in.-> FTD["Frontotemporal Dementia"]
    TDP43 -.Also occurs in.-> AD["Alzheimer's Disease"]

Outgoing (169)

Target	Relation	Type	Str
ALS	associated_with	disease	0.97
UNC13A	regulates	gene	0.95
Lc3Ylation	regulates	process	0.95
Mis-Splicing	causes	mechanism	0.95
Frontotemporal Lobar Degeneration	associated_with	disease	0.95
STATHMIN2	regulates	gene	0.95
Liquid-Liquid Phase Separation	associated_with	process	0.95
Nanocondensates	associated_with	mechanism	0.95
Amyotrophic Lateral Sclerosis	associated_with	disease	0.95
ALS	implicated_in	entity	0.95
ALZHEIMER'S DISEASE	associated_with	entity	0.95
ALS	biomarker_for	entity	0.95
Frontotemporal Dementia	associated_with	disease	0.95
Biomolecular Condensates	involved_in	process	0.95
Stress Granules	involved_in	cell_type	0.93
Mis-splicing	mediates	process	0.92
LC3	regulates	entity	0.92
Fibril Formation	involved_in	process	0.92
UNC13A	causes	protein	0.90
Mitochondrial DNA Release	associated_with	process	0.90
Endothelial Cells	expressed_in	cell_type	0.90
ATG4B	inhibits	entity	0.90
STING	activates	entity	0.90
STMN2	binds	protein	0.90
Cryptic Splicing	inhibits	process	0.90
Blood-Brain Barrier Breakdown	contributes_to	phenotype	0.90
Motor Neuron Degeneration	causes	phenotype	0.90
STATHMIN2	binds	gene	0.90
translation fidelity	regulates	process	0.90
Amyotrophic Lateral Sclerosis	involved_in	disease	0.90
Blood-Brain Barrier	associated_with	process	0.90
MITOCHONDRIAL DNA	causes	entity	0.90
COGNITIVE IMPAIRMENT	contributes_to	entity	0.90
NEURODEGENERATION	contributes_to	entity	0.90
Frontotemporal Dementia	implicated_in	disease	0.90
Amyloid	interacts_with	process	0.90
UNC13A	downregulates	protein	0.89
Phase Transition	associated_with	process	0.88
cGAS/STING Pathway	activates	pathway	0.85
CTNNB1	regulates	protein	0.85
RNA Transcripts	regulates	biomarker	0.85
TAU	co_expressed_with	entity	0.85
Long Terminal Repeat	binds	biomarker	0.85
Pre-mRNA	regulates	compound	0.85
Neuronal Vulnerability	mediates	phenotype	0.85
HIPPOCAMPUS	expressed_in	entity	0.85
HERV-K	regulates	gene	0.85
ALS	involved_in	disease	0.85
Neurodegeneration	associated_with	disease	0.85
TNF/NF-κB Signaling	regulates	pathway	0.80

Incoming (83)

Source	Relation	Type	Str
FMR1	interacts_with	gene	0.95
APOE	regulates	entity	0.90
ATXN2	interacts_with	protein	0.70
ATXN2 polyQ expansions	inhibits	protein	0.70
FTLD	interacts_with	gene	0.70
FUS	co_discussed	gene	0.65
OXIDATIVE_STRESS	regulates	phenotype	0.64
UNC13A	expressed_in	gene	0.60
TDP-43	associated_with	gene	0.60
GFAP	activates	gene	0.60
GFAP	expressed_in	gene	0.60
GFAP	co_discussed	gene	0.60
SOD1	associated_with	gene	0.60
P62	associated_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
FUS	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
FUS	associated_with	gene	0.60
FUS	regulates	gene	0.60
HSPB8	interacts_with	gene	0.60
HSPB8	regulates	gene	0.60
CHCHD10	interacts_with	gene	0.60
CHCHD2	interacts_with	gene	0.60
FUS	biomarker_for	gene	0.60
MLH1	expressed_in	gene	0.60
MSH6	expressed_in	gene	0.60
TARDBP	causes	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
AND	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
DNA	interacts_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
DEMENTIA	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
ALS	associated_with	gene	0.60
INFLAMMATION	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
AND	activates	gene	0.60
ALS	interacts_with	gene	0.60
NEURODEGENERATIVE DISORDERS	expressed_in	gene	0.60
ALS	targets	gene	0.60
RNA	targets	gene	0.60
ALS	regulates	gene	0.60
RNA	regulates	gene	0.60
RNA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TDP43

Understanding Entity Pages

Summary

Wiki Pages (21)

TDP-43 (TAR DNA-Binding Protein 43) - Biomarker

Novel Therapy Index

neuroinflammation

ALS Failed Approaches Analysis

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

prion-disease

Splice-Modulating Therapies for Neurodegeneration

Protein Aggregation Comparison in Neurodegeneration

RNA Metabolism Dysregulation in Alzheimer's Disease

Synaptic Dysfunction in Neurodegeneration

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

Prion Strain Diversity and Selective Vulnerability

ftd-tdp43-pathway

Calcium Dysregulation to Excitotoxicity Pathway

Synaptic Failure in Neurodegeneration

autophagy-lysosome-dysfunction

Stress Granules in Neurodegeneration

Diseases

C9orf72→RNA/Dipeptide Repeat Pathology→ALS/FTD — Causal Chain