STK25

Understanding Entity Pages

This page aggregates everything SciDEX knows about STK25: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

STK25 (YSK1/SOK1) is a serine/threonine kinase involved in stress-activated signaling, cell polarity, and neuronal development, implicated in Alzheimer's, Parkinson's, ALS, and Huntington's diseases.

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graph TD
    STK25["STK25 Serine/Threonine Kinase"]
    PPP1R7["PPP1R7 Protein Phosphatase Regulatory Subunit"]
    PP1["Protein Phosphatase 1"]
    MST4["MST4 Kinase"]
    GOLGI["Golgi Apparatus Structure"]
    CYTOSKELETON["Cytoskeletal Organization"]
    CELL_POLARITY["Cell Polarity Control"]
    AUTOPHAGY["Autophagy Pathway"]
    PROTEIN_AGG["Protein Aggregation"]
    NEURONAL_DEATH["Neuronal Death"]
    ALZHEIMERS["Alzheimer's Disease"]
    PARKINSONS["Parkinson's Disease"]
    OXIDATIVE_STRESS["Oxidative Stress"]
    INFLAMMATION["Neuroinflammation"]

    STK25 -->|"co-expressed with"| PPP1R7
    PPP1R7 -->|"regulates"| PP1
    STK25 -->|"phosphorylates targets"| GOLGI
    STK25 -->|"regulates"| CYTOSKELETON
    STK25 -->|"controls"| CELL_POLARITY
    STK25 -->|"interacts with"| MST4
    
    GOLGI -->|"trafficking defects"| PROTEIN_AGG
    CYTOSKELETON -->|"disruption leads to"| NEURONAL_DEATH
    CELL_POLARITY -->|"loss promotes"| NEURONAL_DEATH
    
    STK25 -->|"dysfunction impairs"| AUTOPHAGY
    AUTOPHAGY -->|"failure increases"| PROTEIN_AGG
    PROTEIN_AGG -->|"triggers"| OXIDATIVE_STRESS
    OXIDATIVE_STRESS -->|"activates"| INFLAMMATION
    INFLAMMATION -->|"promotes"| NEURONAL_DEATH
    
    NEURONAL_DEATH -->|"contributes to"| ALZHEIMERS
    NEURONAL_DEATH -->|"contributes to"| PARKINSONS

    style STK25 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style PPP1R7 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style PP1 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style MST4 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style AUTOPHAGY fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style GOLGI fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style CYTOSKELETON fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style CELL_POLARITY fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style PROTEIN_AGG fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style OXIDATIVE_STRESS fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style INFLAMMATION fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style NEURONAL_DEATH fill:#3a1a1a,stroke:#ef5350,stroke-width:3px
    style ALZHEIMERS fill:#3a2a1a,stroke:#ffa726,stroke-width:2px
    style PARKINSONS fill:#3a2a1a,stroke:#ffa726,stroke-width:2px