concept

SUCCINATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SUCCINATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

2Analyses

9Outgoing

10Incoming

0Experiments

2Debates

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💡 Concept Info

Name	SUCCINATE
Key Genes/Proteins	KDM6A, LYSINE131, SIRT3, SUCCINYL_COA_SYNTHETASE
Related Diseases	DOPAMINE
Related Pathways	NLRP3 INFLAMMASOME

Pathway Diagram

graph TD
    SUCCINATE[SUCCINATE]
    SUCCINATE -->|binds| Bip[Bip]
    SUCCINATE -->|regulates| LYSINE131[LYSINE131]
    SUCCINATE -->|inhibits| DOPAMINE[DOPAMINE]
    SUCCINATE -->|causes| ASTROCYTES[ASTROCYTES]
    SUCCINATE -->|stabilizes| NLRP3_INFLAMMASOME[NLRP3 INFLAMMASOME]
    GPR91[GPR91] -->|binds| SUCCINATE
    oxLDL[oxLDL] -->|upregulates| SUCCINATE
    MIR_369_3P[MIR-369-3P] -->|downregulates| SUCCINATE
    SIRT3[SIRT3] -->|regulates| SUCCINATE
    miR_369_3p[miR_369_3p] -->|regulates| SUCCINATE
    KDM6A[KDM6A] -->|produces| SUCCINATE
    SUCCINYL_COA_SYNTHETASE[SUCCINYL_COA_SYNTHETASE] -->|regulates| SUCCINATE

Outgoing (9)

Target	Relation	Type	Str
Bip	binds	protein	0.85
Oxidative Phosphorylation	associated_with	process	0.80
LYSINE131	regulates	protein	0.72
chromatin regulators	regulates	protein	0.70
DOPAMINE	inhibits	phenotype	0.65
NLRP3 INFLAMMASOME	stabilizes	pathway	0.60
ASTROCYTES	causes	cell_type	0.60
chromatin regulators	modulates	process	0.50
PHD activity	inhibits	phenotype	0.50

Incoming (10)

Source	Relation	Type	Str
GPR91	binds	receptor	0.90
oxLDL	upregulates	compound	0.85
MIR-369-3P	downregulates	gene	0.85
GPR91	interacts_with	protein	0.72
SIRT3	regulates	gene	0.65
miR_369_3p	regulates	gene	0.64
KDM6A	produces	gene	0.60
SUCCINYL_COA_SYNTHETASE	regulates	protein	0.56
NLRP3 INFLAMMASOME	associated_with	pathway	0.50
SUBSTANTIA NIGRA	associated_with	brain_region	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.793

Do microglia actually switch between glycolytic and oxidative phosphorylation as

neuroinflammation | 2026-04-07 | 7 hypotheses Top: 0.609

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The circadian hypothesis assumes metabolic switching drives microglial priming,

closed · Rounds: 4 · Score: 0.66 · 2026-04-21

The study shows VCP-mutant astrocytes exhibit hypoxia response activation withou

closed · Rounds: 4 · Score: 0.78 · 2026-04-13

Related Research

Hypotheses and analyses mentioning SUCCINATE in their description or question text

No additional research found