concept

MIR-369-3P

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MIR-369-3P: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

34Outgoing

9Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	MIR-369-3P
Key Genes/Proteins	IL-1Β, TNF-Α, IL-6, MICRORNAS
Related Diseases	Atherosclerosis, ALS, Inflammation, Diabetes, Als
Related Pathways	Inflammasome Signalling

Pathway Diagram

graph TD
    MIR_369_3P["MIR-369-3P"]
    MIR_369_3P -.protects against.-> Diabetes_Associated_Atheroscle["Diabetes-Associated Atherosclerosis"]
    MIR_369_3P -->|"targets"| GPR91["GPR91"]
    MIR_369_3P -->|"inhibits"| Succinate_GPR91_Signalling["Succinate-GPR91 Signalling"]
    MIR_369_3P -->|"inhibits"| Inflammasome_Signalling["Inflammasome Signalling"]
    MIR_369_3P -->|"expressed in"| Macrophage["Macrophage"]
    MIR_369_3P -->|"downregulates"| IL_1_["IL-1Beta"]
    MIR_369_3P -->|"downregulates"| TNF__["TNF-Alpha"]
    oxLDL["oxLDL"] -->|"downregulates"| MIR_369_3P
    INFLAMMATION["INFLAMMATION"] -->|"inhibits"| MIR_369_3P
    TNF["TNF"] -->|"inhibits"| MIR_369_3P
    IL_6["IL-6"] -->|"inhibits"| MIR_369_3P
    LDLR["LDLR"] -->|"inhibits"| MIR_369_3P
    RNA["RNA"] -->|"activates"| MIR_369_3P
    AND["AND"] -->|"inhibits"| MIR_369_3P

Outgoing (34)

Target	Relation	Type	Str
Diabetes-Associated Atherosclerosis	protects_against	disease	0.95
GPR91	targets	receptor	0.95
GPR91	targets	receptor	0.95
Succinate-GPR91 Signalling	inhibits	pathway	0.92
Inflammasome Activation	inhibits	process	0.90
Inflammasome Signalling	inhibits	pathway	0.90
Macrophage	expressed_in	cell_type	0.90
IL-1Β	downregulates	protein	0.90
TNF-Α	downregulates	protein	0.90
IL-6	downregulates	protein	0.90
Macrophage Immunometabolism	regulates	process	0.85
Succinate	downregulates	compound	0.85
IL-1Β	downregulates	protein	0.85
TNF-Α	downregulates	protein	0.85
IL-6	downregulates	protein	0.85
Macrophage Efferocytosis	upregulates	process	0.80
ATG10	inhibits	gene	0.70
Atherosclerosis	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Als	inhibits	disease	0.65
MICRORNAS	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
Inflammasome	activates	pathway	0.60
IL-6	inhibits	gene	0.60
Macrophage	inhibits	cell_type	0.60
Monocyte	inhibits	cell_type	0.60
TNF	inhibits	gene	0.60
LDLR	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
RNA	activates	gene	0.60
AND	inhibits	gene	0.60
Interleukin	inhibits	protein	0.60

Incoming (9)

Source	Relation	Type	Str
oxLDL	downregulates	compound	0.90
oxLDL	downregulates	compound	0.85
INFLAMMATION	inhibits	gene	0.60
TNF	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
LDLR	inhibits	gene	0.60
RNA	activates	gene	0.60
AND	inhibits	gene	0.60
MICRORNAS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found