protein

NLRP3 INFLAMMASOME

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLRP3 INFLAMMASOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

874Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	NLRP3 INFLAMMASOME
Associated Diseases	AGING, ALZHEIMER'S DISEASE, APOPTOSIS, ATP, AUTISM, AUTOPHAGY
Known Drugs/Compounds	FINGOLIMOD, BERBERINE, METFORMIN, FISETIN, SEMAGLUTIDE, EMPAGLIFLOZIN
KG Connections	351 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"activates"| Microglia["Microglia"]
    style Microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"causes"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"associated"| IL_1_["IL-1Beta"]
    style IL_1_ fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"involved in"| Inflammatory_Diseases["Inflammatory Diseases"]
    style Inflammatory_Diseases fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"associated"| Alzheimer_s_Disease["Alzheimer's Disease"]
    style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"involved in"| Glaucoma["Glaucoma"]
    style Glaucoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"] -->|"causes"| Retinal_Ganglion_Cell_Death["Retinal Ganglion Cell Death"]
    style Retinal_Ganglion_Cell_Death fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    USP22["USP22"] -.->|"inhibits"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style USP22 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    USP5["USP5"] -.->|"inhibits"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style USP5 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NF__B["NF-kappaB"] -->|"activates"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style NF__B fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    __SYNUCLEIN["Alpha-SYNUCLEIN"] -->|"activates"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style __SYNUCLEIN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Macrophage["Macrophage"] -->|"expressed in"| NLRP3_INFLAMMASOME["NLRP3 INFLAMMASOME"]
    style Macrophage fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style NLRP3_INFLAMMASOME fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (313)

Target	Relation	Type	Str
Microglia	activates	cell_type	0.95
Neuroinflammation	causes	process	0.90
IL-1Β	associated_with	protein	0.90
Inflammatory Diseases	involved_in	disease	0.90
Alzheimer's Disease	associated_with	disease	0.90
Glaucoma	involved_in	disease	0.90
Retinal Ganglion Cell Death	causes	phenotype	0.90
Neuroinflammation	activates	process	0.90
Pyroptosis	associated_with	process	0.90
Alzheimer's Disease	contributes_to	disease	0.88
Microglial Phagocytic Function	inhibits	process	0.88
Multiple Sclerosis	involved_in	disease	0.85
Alzheimer's Disease	involved_in	disease	0.85
Parkinson's Disease	involved_in	disease	0.85
Cognitive Decline	involved_in	phenotype	0.85
STROKE	protects_against	disease	0.70
NEURODEGENERATION	exacerbates	phenotype	0.70
TAU	causes	protein	0.70
NRF2	interacts_with	gene	0.70
ATG5	degrades	gene	0.65
CASP1	degrades	gene	0.65
FIBROSIS	causes	disease	0.65
ASTROCYTES	causes	cell_type	0.65
DEMENTIA	causes	disease	0.65
OXALIPLATIN	protects_against	drug	0.65
INFLAMMATION	causes	phenotype	0.65
PYROPTOSIS	causes	phenotype	0.65
MACROPHAGES	treats	cell_type	0.65
MYELOID CELLS	interacts_with	cell_type	0.65
INFLAMMATION	treats	phenotype	0.65
GLUTAMATE EXCITOTOXICITY	activates	phenotype	0.65
MLKL	inhibits	gene	0.65
MICROGLIA	treats	cell_type	0.65
PYROPTOSIS	degrades	phenotype	0.65
HEPATOCYTES	causes	cell_type	0.65
HDAC3	degrades	gene	0.65
COGNITIVE DECLINE	causes	phenotype	0.65
STAT3	phosphorylates	gene	0.65
MITOPHAGY	regulates	phenotype	0.65
SYNAPTIC PLASTICITY	treats	phenotype	0.65
NEURONS	causes	cell_type	0.65
ALZHEIMER'S DISEASE	causes	disease	0.65
PINK1	activates	gene	0.65
ENDOTHELIAL CELLS	activates	cell_type	0.65
SYNAPTIC LOSS	activates	phenotype	0.65
NEURONS	activates	cell_type	0.65
NEURONS	treats	cell_type	0.65
OXIDATIVE STRESS	treats	phenotype	0.65
PYROPTOSIS	regulates	phenotype	0.65
NEUROINFLAMMATION	activates	phenotype	0.65

Incoming (561)

Source	Relation	Type	Str
NF-κB	activates	pathway	0.87
Α-SYNUCLEIN	activates	protein	0.85
Macrophage	expressed_in	cell_type	0.85
Mitophagy	inhibits	process	0.80
MICROGLIA	protects_against	cell_type	0.70
TAU	activates	protein	0.70
APP	activates	gene	0.70
HDAC3	inhibits	gene	0.70
ISCHEMIA	inhibits	disease	0.70
ALS	causes	disease	0.70
SYK	causes	gene	0.65
SYK	activates	gene	0.65
NEURONS	interacts_with	cell_type	0.65
TREM2	exacerbates	gene	0.65
MICROGLIA	degrades	cell_type	0.65
MICROGLIA	causes	cell_type	0.65
DRD2	inhibits	gene	0.65
DRD2	regulates	gene	0.65
NEURODEGENERATION	treats	phenotype	0.65
MITOCHONDRIAL DYSFUNCTION	activates	phenotype	0.65
HEPATOCYTES	protects_against	cell_type	0.65
HEPATOCYTES	activates	cell_type	0.65
HEPATOCYTES	inhibits	cell_type	0.65
HEPATOCYTES	targets	cell_type	0.65
OBESITY	produces	disease	0.65
STING PATHWAY	activates	pathway	0.65
TH	activates	gene	0.65
JNK	inhibits	gene	0.65
BRD4	inhibits	gene	0.65
BRD4	treats	gene	0.65
BRD4	regulates	gene	0.65
BRD4	protects_against	gene	0.65
BRD4	activates	gene	0.65
HDAC3	activates	gene	0.65
GLUTAMATE	activates	phenotype	0.65
NECROPTOSIS	regulates	phenotype	0.65
MICROGLIAL ACTIVATION	activates	phenotype	0.65
BERBERINE	treats	drug	0.65
BERBERINE	inhibits	drug	0.65
PYROPTOSIS	exacerbates	phenotype	0.65
MITOCHONDRIAL DYSFUNCTION	exacerbates	phenotype	0.65
HDAC6	activates	gene	0.65
NECROPTOSIS	interacts_with	phenotype	0.65
TRAUMATIC BRAIN INJURY	inhibits	disease	0.65
METFORMIN	inhibits	drug	0.65
MITOPHAGY	treats	phenotype	0.65
MITOPHAGY	inhibits	phenotype	0.65
FISETIN	inhibits	drug	0.65
MICROGLIA	inhibits	cell_type	0.65
MICROGLIA	regulates	cell_type	0.65

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.599	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NLRP3 INFLAMMASOME

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

CBS/PSP Supplements Guide

Atypical Parkinsonism

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Alzheimer's Disease Mechanism Index

Therapeutics

neuroinflammation

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

TREM2 Mechanism Hub

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

GSK-3β in Neurodegeneration

Mitochondrial Dysfunction in Parkinson's Disease

Autophagy Mechanisms

APOC4 — Apolipoprotein C-IV