gene

BIP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BIP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

187Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

BIP (HSPA5/GRP78) is a major ER chaperone and key regulator of the unfolded protein response in neurodegeneration

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🧬 Gene Info

Gene Symbol	BIP
Full Name	Binding Immunoglobulin Protein
Aliases	HSPA5/GRP78
Protein Type	Protein
Function	De Novo Folding: Binds nascent polypeptide chains as they enter the ER via the Sec61 translocon
Subcellular Localization	the ER lumen. Its primary functions include:
Molecular Weight	78 kDa
Amino Acids	654 aa
Pathways	Autophagy, Mapk, Mtor, Pi3K/Akt, Unfolded Protein Response
UniProt ID	P11021
GeneCards	BIP
Human Protein Atlas	BIP
Protein folding assistance	BIP binds to nascent polypeptides and ensures proper folding by preventing aggregation
ER quality control	BIP monitors protein folding status and targets misfolded proteins for degradation
UPR regulation	BIP acts as the primary sensor for ER stress, controlling activation of three UPR branches:
Associated Diseases	Tumor
Interactions	JNK1, JNK2, CHOP, JUN, P38, TSC2
KG Connections	181 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: BIP — AlphaFold P11021 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    BIP["BIP"] -->|"activates"| Als["Als"]
    BIP["BIP"] -->|"activates"| Ms["Ms"]
    BIP["BIP"] -->|"regulates"| Ms["Ms"]
    BIP["BIP"] -->|"regulates"| Cancer["Cancer"]
    BIP["BIP"] -->|"activates"| Tumor["Tumor"]
    BIP["BIP"] -->|"interacts with"| Ms["Ms"]
    BIP["BIP"] -->|"therapeutic target"| Ms["Ms"]
    BIP["BIP"] -->|"therapeutic target"| Neurodegeneration["Neurodegeneration"]
    BIP["BIP"] -.->|"inhibits"| Cancer["Cancer"]
    BIP["BIP"] -->|"associated with"| Tumor["Tumor"]
    BIP["BIP"] -->|"activates"| ALS["ALS"]
    BIP["BIP"] -->|"activates"| JNK1["JNK1"]
    style BIP fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style JNK1 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (120)

Target	Relation	Type	Str
Endoplasmic Reticulum Stress Response	involved_in	process	0.85
Als	activates	disease	0.85
Inflammation	activates	disease	0.85
Er Stress	activates	pathway	0.80
Autophagy	activates	pathway	0.80
Tumor	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
CHOP	activates	gene	0.70
Unfolded Protein Response	activates	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Apoptosis	activates	pathway	0.70
Ms	activates	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ms	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
ALS	activates	disease	0.65
Stroke	activates	disease	0.65
Ischemia	activates	disease	0.65
Cancer	activates	disease	0.65
Obesity	regulates	disease	0.65
Nafld	regulates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Fatty Liver	regulates	disease	0.65
Senescence	activates	disease	0.65
Obesity	activates	disease	0.65
Anxiety	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	inhibits	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Bipolar	expressed_in	disease	0.65
Inflammation	interacts_with	disease	0.65
Parkinson	inhibits	disease	0.65
ALS	inhibits	disease	0.65
JNK1	activates	gene	0.60
JNK2	activates	gene	0.60
JUN	activates	gene	0.60
P38	activates	gene	0.60
TSC2	activates	gene	0.60
EIF2AK3	activates	gene	0.60
GSK3B	activates	gene	0.60
ERN1	activates	gene	0.60
HSPA5	activates	gene	0.60
HSP70	associated_with	gene	0.60
ATF6	interacts_with	gene	0.60
HSPA5	associated_with	gene	0.60
MUL1	inhibits	gene	0.60

Incoming (67)

Source	Relation	Type	Str
AUTOPHAGY	activates	gene	0.70
ROS	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
JUN	activates	gene	0.60
P38	activates	gene	0.60
JNK2	activates	gene	0.60
JNK1	activates	gene	0.60
ATF4	activates	gene	0.60
ATF6	activates	gene	0.60
PIK3C3	activates	gene	0.60
YWHAG	activates	gene	0.60
RICTOR	activates	gene	0.60
AKT	activates	gene	0.60
ENDOG	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
NTS	inhibits	gene	0.60
GAIN	activates	gene	0.60
PERK	activates	gene	0.60
SQSTM1	activates	gene	0.60
PI3K	regulates	gene	0.60
PLIN2	activates	gene	0.60
FOS	activates	gene	0.60
STAT3	activates	gene	0.60
BDNF	activates	gene	0.60
MMP2	activates	gene	0.60
ARC	activates	gene	0.60
PTEN	activates	gene	0.60
IL6	activates	gene	0.60
MMP9	activates	gene	0.60
NGF	activates	gene	0.60
IGF1	activates	gene	0.60
BAX	activates	gene	0.60
BAX	inhibits	gene	0.60
ERN1	activates	gene	0.60
HSPA5	activates	gene	0.60
TSC2	activates	gene	0.60
GSK3B	activates	gene	0.60
EIF2AK3	activates	gene	0.60
C-JUN	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
MTORC1	activates	gene	0.60
NFKB	inhibits	gene	0.60
STROKE	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
LYSOSOME	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
ANXIETY	activates	gene	0.60
GENES	activates	gene	0.60
DGAT2	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the optimal temporal windows for TREM2 inhibition vs activation in Alzh

neurodegeneration | 2026-04-11 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BIP

Understanding Entity Pages

Summary

Wiki Pages (21)

BIP — Binding Immunoglobulin Protein

GBA1→GCase→Lysosome→PD Causal Chain

Metabolomic Alterations in PSP

tudca-udca-neurodegeneration

er-stress-neurodegeneration

Unfolded Protein Response (UPR)

Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases

TOR1A Gene

Neurotrophic Factors in Neurodegeneration

Endoplasmic Reticulum Stress Comparison Across Neurodegenerative Diseases

PKR Pathway in Neurodegeneration

endoplasmic-reticulum-stress

Apoptosis in Neurodegeneration

Shared Proteinostasis Failure in Alzheimer's and Parkinson's Disease

GBA Gene Mutations and Parkinson's Disease Risk

ERP57 (PDIA3) — Protein Disulfide Isomerase Family A Member 3

ATF3 Protein

ER Stress in Corticobasal Syndrome

Sigma-1 Receptor Signaling in Neurodegeneration

SURF4 — SURF4 Homolog